9H-Fluorene, 9-[(2-methylphenyl)methylene]-

Base Information

• Chemical Name: 9H-Fluorene, 9-[(2-methylphenyl)methylene]-
• CAS No.: 67535-55-1
• Molecular Formula: C21H16
• Molecular Weight: 268.358
• Mol file: 67535-55-1.mol

Synonyms:

Chemical Property of 9H-Fluorene, 9-[(2-methylphenyl)methylene]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9H-Fluorene, 9-[(2-methylphenyl)methylene]-

There total 11 articles about 9H-Fluorene, 9-[(2-methylphenyl)methylene]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-Fmoc-L-Ile-NHCH2Ph → 9-(4-methylbenzylidene)-9H-fluorene (2871-85-4) + 9-(2-methylbenzylidene)-9H-fluorene (67535-55-1) + (S)-isoleucine benzyl amide (129253-02-7)

Guidance literature:

With hydrogenchloride; aluminium trichloride; sodium hydrogencarbonate; In chloroform; water; toluene; at 20 ℃; for 3h;

DOI:10.1002/(SICI)1099-0690(200002)2000:4<573::AID-EJOC573>3.0.CO;2-I

Reference yield: 88.0%

2-iodobiphenyl (2113-51-1) + 1-(2-bromovinyl)-2-methylbenzene (394698-73-8) → 9-(2-methylbenzylidene)-9H-fluorene (67535-55-1)

Guidance literature:

With palladium diacetate; potassium carbonate; tris-(o-tolyl)phosphine; In dimethyl sulfoxide; at 120 ℃; for 24h; Schlenk technique; Sealed tube; Inert atmosphere;

DOI:10.1039/d1ob01547h

Reference yield: 86.0%

methyl 2-(((9H-fluoren-9-yl)methoxy)carbonyl)aminopropanoate (146346-88-5) → L-Alanine methyl ester (10065-72-2) + 9-(4-methylbenzylidene)-9H-fluorene (2871-85-4) + 9-(2-methylbenzylidene)-9H-fluorene (67535-55-1)

Guidance literature:

With hydrogenchloride; aluminium trichloride; sodium hydrogencarbonate; In chloroform; water; toluene; at 20 ℃; for 3h;

DOI:10.1002/(SICI)1099-0690(200002)2000:4<573::AID-EJOC573>3.0.CO;2-I

upstream raw materials:

9-fluorenone

[(2-methylphenyl)methyl]triphenylphosphonium bromide

ethanol

Trimethyl-[9-(2-methyl-benzyl)-9H-fluoren-9-yl]-ammonium

Refernces

• 1、 Ma, Yu-Chuan,Luo, Jin-Yun,Zhang, Shi-Chu,Lu, Shu-Hui,Du, Guang-Fen,He, Lin. "An N-heterocyclic carbene-catalyzed switchable reaction of 9-(trimethylsilyl)fluorene and aldehydes: Chemoselective synthesis of dibenzofulvenes and fluorenyl alcohols". supporting information. p. 3717 - 3721. Retrieved 2021/05/04.
• 2、 Casarini, Daniele,Lunazzi, Lodovico,Mazzanti, Andrea. "Correlated rotations in benzylfluorene derivatives: Structure, conformation, and stereodynamics". . p. 2811 - 2818. Retrieved 2008/09/19.