desmethylofloxacin

Base Information

• Chemical Name: desmethylofloxacin
• CAS No.: 82419-46-3
• Molecular Formula: C₁₇H₁₈FN₃O₄
• Molecular Weight: 347.346
• Mol file: 82419-46-3.mol

Synonyms:DL 8165; DP1764

Chemical Property of desmethylofloxacin

Chemical Property:

• Vapor Pressure: 5.06E-14mmHg at 25°C
• Boiling Point: 574.2°C at 760 mmHg
• Flash Point: 301°C
• PSA: 75.01000
• Density: 1.52g/cm³
• LogP: 0.98590

Purity/Quality:

92%+ ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of desmethylofloxacin

There total 8 articles about desmethylofloxacin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

1-methyl-piperazine (109-01-3) + 9,10-difluoro-7-oxo-2,3-dihydro-7H-pyrido<1,2,3-de><1,4>benzoxazine-6-carboxylic acid (82419-31-6) → marbofloxacin (82419-46-3)

Guidance literature:

In dimethyl sulfoxide; at 100 - 140 ℃; for 6h;

DOI:10.1248/cpb.32.4907

Reference yield: 21.0%

fleroxacin (79660-72-3) → C13H12F2N2O3 (1136506-05-2) + C17H19F2N3O4 (1136506-04-1) + marbofloxacin (82419-46-3)

Guidance literature:

With water; Photolysis;

DOI:10.1021/ol900189v

Reference yield:

2,3,4-trifluoronitrobenzene (771-69-7) → marbofloxacin (82419-46-3)

Guidance literature:

Multi-step reaction with 7 steps

1: 29 percent / 10percent KOH / H₂O; dimethylsulfoxide / 2 h / 18 - 20 °C

2: 61 percent / K₂CO₃ / dimethylformamide / 2.5 h / 80 - 100 °C

3: 28 percent / sodium hydrosulfite / methanol; H₂O / 1 h / Ambient temperature

4: 97 percent / K₂CO₃ / dimethylformamide / 1 h / 80 - 100 °C

5: 2.) PPE / 1.) 130-135 deg C, 2h; 2.) 140-145 deg C, 1.5h

6: 75 percent / conc. HCl / acetic acid / 4 h / 100 - 110 °C

7: 41 percent / dimethylsulfoxide / 6 h / 100 - 140 °C

With hydrogenchloride; potassium hydroxide; sodium disulfite; potassium carbonate; In methanol; water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1248/cpb.32.4907

upstream raw materials:

1-methyl-piperazine

9,10-difluoro-7-oxo-2,3-dihydro-7H-pyrido<1,2,3-de><1,4>benzoxazine-6-carboxylic acid

2,3,4-trifluoronitrobenzene

2,3-difluoro-6-nitrophenol

Refernces

• 1、 Hayakawa,Hiramitsu,Tanaka. "Synthesis and antibacterial activities of substituted 7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acids". . p. 4907 - 4913. Retrieved 2007/10/02.