Technology Process of [1,1'-Biphenyl]-2-carboxylic acid,
4'-[[4-methyl-6-(5-methyl-2-benzoxazolyl)-2-propyl-1H-benzimidazol-1-yl
]methyl]-, methyl ester
There total 10 articles about [1,1'-Biphenyl]-2-carboxylic acid,
4'-[[4-methyl-6-(5-methyl-2-benzoxazolyl)-2-propyl-1H-benzimidazol-1-yl
]methyl]-, methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 74.3 percent / sulfuric acid / 2 h / Heating
2: 92.1 percent / aq. hydrazine / Raney Ni / methanol / 20 °C
3: 79.6 percent / triethylamine / CH2Cl2 / 1 h / 20 °C
4: 75.6 percent / nitric acid / 1.5 h / -20 - -15 °C
5: 92 percent / aq. hydrazine / Raney Ni / methanol / 20 °C
6: 90 percent / acetic acid / 2 h / Heating
7: 82.3 percent / NaOH; water / methanol / 2 h / Heating
8: 67.1 percent / polyphosphoric acid / 20 h / 160 °C
9: 84.7 percent / NaH / 1,2-dimethoxy-ethane / 4 h / 20 °C
With
sodium hydroxide; PPA; sulfuric acid; water; nitric acid; sodium hydride; hydrazine hydrate; triethylamine;
nickel;
In
methanol; 1,2-dimethoxyethane; dichloromethane; acetic acid;
DOI:10.1002/jhet.5570400623
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 79.6 percent / triethylamine / CH2Cl2 / 1 h / 20 °C
2: 75.6 percent / nitric acid / 1.5 h / -20 - -15 °C
3: 92 percent / aq. hydrazine / Raney Ni / methanol / 20 °C
4: 90 percent / acetic acid / 2 h / Heating
5: 82.3 percent / NaOH; water / methanol / 2 h / Heating
6: 67.1 percent / polyphosphoric acid / 20 h / 160 °C
7: 84.7 percent / NaH / 1,2-dimethoxy-ethane / 4 h / 20 °C
With
sodium hydroxide; PPA; water; nitric acid; sodium hydride; hydrazine hydrate; triethylamine;
nickel;
In
methanol; 1,2-dimethoxyethane; dichloromethane; acetic acid;
DOI:10.1002/jhet.5570400623