Noscapine

Base Information Edit

Chemical Name:Noscapine
CAS No.:6035-40-1
Deprecated CAS:8055-18-3,8057-19-0,567-86-2,1368-39-4
Molecular Formula:C₂₂H₂₃NO₇
Molecular Weight:413.427
Hs Code.:
European Community (EC) Number:204-899-2
NSC Number:121869,5366
UNII:8V32U4AOQU,A4C6WE7BZN
DSSTox Substance ID:DTXSID4023385,DTXSID901032089
Nikkaji Number:J9.283E
Wikipedia:Noscapine
Wikidata:Q415619
NCI Thesaurus Code:C80589
Pharos Ligand ID:Z9WGQBHQ8UVV
Metabolomics Workbench ID:46045
ChEMBL ID:CHEMBL364713
Mol file:6035-40-1.mol

Synonyms:Capval;Capval Tropfen;Embonate, Noscapine Hydrogen;Hydrochloride, Noscapine;Hydrogen Embonate, Noscapine;Librochin prikkelhoest;Narcotine;Noscapect;Noscapine;Noscapine Hydrochloride;Noscapine Hydrogen Embonate;prikkelhoest, Librochin;Tropfen, Capval;Tuscalman

Suppliers and Price of Noscapine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 9 raw suppliers

Chemical Property of Noscapine Edit

Chemical Property:

Vapor Pressure:8.42E-13mmHg at 25°C
Boiling Point:565.3°Cat760mmHg
Flash Point:295.7°C
Density:1.332g/cm³
XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:413.14745207
Heavy Atom Count:30
Complexity:647

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCC2=CC3=C(C(=C2C1C4C5=C(C(=C(C=C5)OC)OC)C(=O)O4)OC)OCO3
Isomeric SMILES:CN1CCC2=CC3=C(C(=C2[C@@H]1[C@@H]4C5=C(C(=C(C=C5)OC)OC)C(=O)O4)OC)OCO3
Recent ClinicalTrials:Study of Noscapine for Patients With Low Grade Non Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia Refractory to Chemotherapy
Recent EU Clinical Trials:A randomised, two-period two-stage cross-over study on the relative bioavailability of two different liquid formulations of single noscapine doses (phase I/IV, open-label) in healthy volunteers (fasted state)

Technology Process of Noscapine

There total 55 articles about Noscapine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: (+/-)-α-3-(9-bromo-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-6,7-dimethoxy-1(3H)-isobenzofuranone

: 128-62-1,3860-46-6,6035-40-1,10421-76-8,35933-62-1,35933-63-2,35933-64-3,85280-20-2
(±)-α-noscapine

Guidance literature:: With hydrogen; triethylamine; for 30h;
DOI:10.1016/j.tet.2011.05.060

Reference yield: 46.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 36017-64-8
(+/-)-erythro-1-<1'-(4',5'-dimethoxyphthalidyl)>-8-methoxy-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline

: 128-62-1,3860-46-6,6035-40-1,10421-76-8,35933-62-1,35933-63-2,35933-64-3,85280-20-2
(±)-α-noscapine

Guidance literature:: With formic acid; In water; at 100 ℃; for 0.166667h;

Reference yield: 42.0%

: 30936-27-7
4-methoxy-6-methyl-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinolin-6-ium iodide

: 133932-07-7
6,7-dimethoxy-3-(trimethylsilyl)isobenzofuran-1(3H)-one

: 128-62-1,3860-46-6,6035-40-1,10421-76-8,35933-62-1,35933-63-2,35933-64-3,85280-20-2
(±)-α-noscapine

Guidance literature:: With potassium hydrogen difluoride; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.3987/COM-13-12843