Dimethyl phenylphosphonite

Base Information

• Chemical Name: Dimethyl phenylphosphonite
• CAS No.: 2946-61-4
• Molecular Formula: C8H11O2P
• Molecular Weight: 170.148
• Hs Code.: 2931900090
• European Community (EC) Number: 220-960-6
• UNII: 9AN05LG4JZ
• DSSTox Substance ID: DTXSID60183666
• Nikkaji Number: J150.034A
• Wikidata: Q72468360
• Mol file: 2946-61-4.mol

Synonyms:Dimethyl phenylphosphonite;2946-61-4;Dimethoxyphenylphosphine;dimethoxy(phenyl)phosphane;Phenyldimethoxyphosphine;DIMethylphenYLPHOSPHONITE;Phosphonous acid, phenyl-, dimethyl ester;Phosphonous acid, P-phenyl-, dimethyl ester;Phosphorus, dimethoxy phenyl;9AN05LG4JZ;EINECS 220-960-6;phenylphosphonous acid dimethyl ester;MFCD00008352;PhP(OMe)2;UNII-9AN05LG4JZ;SCHEMBL196040;Dimethyl phenylphosphonite, 97%;DTXSID60183666;CAA94661;AKOS004908691;CS-0106870;D5014;FT-0625042;F17185;J-017531

Chemical Property of Dimethyl phenylphosphonite

Chemical Property:

• Appearance/Colour: Clear colorless liquid
• Vapor Pressure: 0.628mmHg at 25°C
• Refractive Index: n20/D 1.529(lit.)
• Boiling Point: 194.1 °C at 760 mmHg
• Flash Point: 81 °C
• PSA: 32.05000
• Density: 1.072 g/mL at 25 °C(lit.)
• LogP: 1.91660
• Storage Temp.: 0-6°C
• Sensitive.: Air Sensitive
• Water Solubility.: Miscible with alcohol. Immiscible with water.
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 170.04966659
• Heavy Atom Count: 11
• Complexity: 98.3

Purity/Quality:

Dimethyl Phenylphosphonite >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Phosphite Compounds
• Canonical SMILES: COP(C1=CC=CC=C1)OC
• Uses: Dimethyl phenylphosphonite is used in the preparation of phenyl-phosphonic acid dimethyl ester. It is used as a precursor for the preparation of dinitrosyltris(dimethyl phenylphosphonite)manganese(I) tetrafluoroborate.

Technology Process of Dimethyl phenylphosphonite

There total 27 articles about Dimethyl phenylphosphonite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methanol (67-56-1) + Dichlorophenylphosphine (644-97-3) → phenylphosphonous acid dimethyl ester (2946-61-4)

Guidance literature:

Dichlorophenylphosphine; With pyridine; In hexane; Inert atmosphere; Cooling with ice;

methanol; In hexane; at 0 - 26 ℃; for 17h; Inert atmosphere;

DOI:10.1002/ejoc.202000035

Reference yield: 90.0%

methanol (67-56-1) + Phenylmethoxydifluorphosphoran (71530-36-4,127643-04-3) → phenylphosphonous acid dimethyl ester (2946-61-4)

Guidance literature:

With triethylamine; at 37 ℃;

Reference yield: 65.0%

P,P-dichlorophenylphosphine oxide (824-72-6) → phenylphosphonous acid dimethyl ester (2946-61-4)

Guidance literature:

In methanol; benzene;

upstream raw materials:

N,N-dimethyl-aniline

Dichlorophenylphosphine

diethyl ether

sodium methylate

Downstream raw materials:

β-(methoxy-phenyl-phosphinoyl)-isobutyric acid methyl ester

phenyl-phosphonic acid isopropenyl ester-methyl ester

phenyl-phosphonic acid-(2,2-dichloro-vinyl ester)-methyl ester

acetyl-phenyl-phosphinic acid methyl ester

Refernces

• 1、 Chamkin, Aleksandr A.,Krivykh, Vasily V.,Kreindlin, Arkady Z.,Dolgushin, Fedor M.,Ustynyuk, Nikolai A.. "Reactions of Ferrocenium Hexafluorophosphate with P?OR Nucleophiles Give Ring C?H Functionalization or Ring Replacement Products Depending on the Phosphorus Reagent". . p. 1601 - 1610. Retrieved 2021/04/16.
• 2、 Bagi, Péter,Fogassy, Elemér,Herbay, Réka,Holczbauer, Tamás,Keglevich, Gy?rgy,Mátrav?lgyi, Béla,Madarász, János,Székely, Gy?rgy,Varga, Bence. "Scalable Enantiomeric Separation of Dialkyl-Arylphosphine Oxides Based on Host–Guest Complexation with TADDOL-Derivatives, and their Recovery". supporting information. . Retrieved 2020/03/23.