2-Adamantanone oxime

Base Information

• Chemical Name: 2-Adamantanone oxime
• CAS No.: 4500-12-3
• Molecular Formula: C10H15NO
• Molecular Weight: 165.235
• Hs Code.: 29280000
• Mol file: 4500-12-3.mol

Synonyms:2-Adamantanone,oxime (6CI,7CI,8CI);Tricyclo[3.3.1.13,7]decanone, oxime (9CI);2-Hydroxyiminoadamantane;Adamantanone oxime;NSC 127840;2-Adamantanone oxime;

Chemical Property of 2-Adamantanone oxime

Chemical Property:

• Appearance/Colour: white solid
• Vapor Pressure: 0.000409mmHg at 25°C
• Melting Point: 164-167 °C
• Refractive Index: 1.752
• Boiling Point: 294 °C at 760 mmHg
• PKA: 12.46±0.20(Predicted)
• Flash Point: 175.6 °C
• PSA: 32.59000
• Density: 1.5 g/cm³
• LogP: 2.27270
• Sensitive.: Moisture Sensitive
• Solubility.: soluble in Methanol

Purity/Quality:

98.5% ^*data from raw suppliers

2-Adamantanone Oxime >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2-Adamantanone oxime

There total 13 articles about 2-Adamantanone oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Adamantanone (700-58-3) → 2-adamantanone oxime (4500-12-3)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In ethanol; at 60 ℃; for 2h;

DOI:10.1007/s00044-016-1554-6

Reference yield: 63.0%

N-(2-adamantyl)amine (13074-39-0) → 2-adamantanone oxime (4500-12-3) + Di-adamantan-2-yl-diazene N,N'-dioxide (32899-07-3,119135-73-8)

Guidance literature:

With sodium percarbonate; N,N,N',N'-tetraacetylethylenediamine; sodium hydrogencarbonate; In dichloromethane; water; for 3h; Ambient temperature;

Reference yield: 60.0%

2-chloro-2-nitrosoadamantane (33673-34-6) + neopentylmagnesium bromide (33974-41-3) → 2-Adamantanone (700-58-3) + 2-adamantanone oxime (4500-12-3) + adamantanone oxime O-neo-pentyl ether + α,α-adamantylidene-N-neopentyl nitrone

Guidance literature:

In diethyl ether; at 0 ℃; for 0.166667h;

upstream raw materials:

methyl magnesium iodide

2-chloro-2-nitrosoadamantane

2-Adamantanone

n-butyl magnesium bromide

Downstream raw materials:

3-[1-Phenyl-meth-(Z)-ylideneaminooxy]-propionic acid ethyl ester

(E)-O-(o-methoxycinnamoyl)-2-adamantanone oxime

2-Adamantanone

2-nitroiminoadamantane

Refernces

• 1、 Liu, Sheng,Li, Yubin,Wei, Wanxing,Wei, Jingchen. "Synthesis and biological evaluation of phenylpropanoid derivatives". . p. 1074 - 1086. Retrieved 2016/07/06.
• 2、 -. "CENTRALLY ACTIVE AND ORALLY BIOAVAILABLE ANTIDOTES FOR ORGANOPHOSPHATE EXPOSURE AND METHODS FOR MAKING AND USING THEM". Page/Page column 50; 51. . Retrieved 2014/09/03.