Technology Process of Benzoic acid, 2-[[1-(phenylsulfonyl)-1H-indol-3-yl]carbonyl]-, methyl
ester
There total 8 articles about Benzoic acid, 2-[[1-(phenylsulfonyl)-1H-indol-3-yl]carbonyl]-, methyl
ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl 2-(1H-indole-3-carbonyl)benzoate;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 ℃;
for 0.5h;
benzenesulfonyl chloride;
In
tetrahydrofuran;
DOI:10.1055/s-2004-815397
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 86 percent / NaH / benzene; various solvent(s) / 5 h / Heating
2.1: 65 percent / K2CO3 / dimethylsulfoxide / 23 h / 85 - 90 °C
3.1: 94 percent / NaOMe / 0.5 h / Heating
4.1: 96 percent / H2 / Pd/C / methanol / 1.25 h / 20 °C / 760 Torr
5.1: 67 percent / POBr3 / methoxybenzene / 2 h / 20 °C
6.1: 88 percent / H2; Et3N / Pd/C / methanol / 0.25 h / 20 °C / 760 Torr
7.1: 72 percent / benzeneseleninic anhydride / chlorobenzene / 0.5 h / 80 °C
8.1: LDA / tetrahydrofuran / 0.5 h / -78 °C
8.2: 95 percent / tetrahydrofuran
With
benzeneseleninic anhydride; hydrogen; sodium methylate; sodium hydride; potassium carbonate; triethylamine; lithium diisopropyl amide; phosphorus(V) oxybromide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dimethyl sulfoxide; methoxybenzene; chlorobenzene; benzene;
DOI:10.1055/s-2004-815397
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 88 percent / H2; Et3N / Pd/C / methanol / 0.25 h / 20 °C / 760 Torr
2.1: 72 percent / benzeneseleninic anhydride / chlorobenzene / 0.5 h / 80 °C
3.1: LDA / tetrahydrofuran / 0.5 h / -78 °C
3.2: 95 percent / tetrahydrofuran
With
benzeneseleninic anhydride; hydrogen; triethylamine; lithium diisopropyl amide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; chlorobenzene;
DOI:10.1055/s-2004-815397
