7-(3-oxocholest-4-en-2-yl)-5-oxa-4-oxoheptanoic acid

Base Information

• Chemical Name: 7-(3-oxocholest-4-en-2-yl)-5-oxa-4-oxoheptanoic acid
• CAS No.: 134329-94-5
• Molecular Formula: C₃₃H₅₂O₅
• Molecular Weight: 528.773
• Mol file: 134329-94-5.mol

Synonyms:7-(3-oxocholest-4-en-2-yl)-5-oxa-4-oxoheptanoic acid

Chemical Property of 7-(3-oxocholest-4-en-2-yl)-5-oxa-4-oxoheptanoic acid

Chemical Property:

• Vapor Pressure: 5.07E-18mmHg at 25°C
• Boiling Point: 639.9°Cat760mmHg
• Flash Point: 195.4°C
• PSA: 80.67000
• Density: 1.09g/cm³
• LogP: 7.62110

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-(3-oxocholest-4-en-2-yl)-5-oxa-4-oxoheptanoic acid

There total 5 articles about 7-(3-oxocholest-4-en-2-yl)-5-oxa-4-oxoheptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

succinic acid anhydride (108-30-5) + 2α-(2'-hydroxyethyl)cholest-4-en-3-one (134329-93-4) → 7-(3-oxocholest-4-en-2α-yl)-5-oxa-4-oxoheptanoic acid (134329-94-5)

Guidance literature:

With pyridine; 1H-imidazole; for 5h; Heating;

DOI:10.1016/0039-128X(91)90080-F

Reference yield:

2-methylenecholest-4-en-3-one (127063-81-4) → 7-(3-oxocholest-4-en-2α-yl)-5-oxa-4-oxoheptanoic acid (134329-94-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMSO, RT, 45 min, 2.) DMSO, THF, RT, 5 h

2: 76 percent / NaI, TMSCl / acetonitrile / 2 h / Ambient temperature

3: 88 percent / NaOH / tetrahydrofuran; H₂O / 9 h / Ambient temperature

4: 43 percent / imidazole, pyridine / 5 h / Heating

With pyridine; 1H-imidazole; sodium hydroxide; chloro-trimethyl-silane; sodium hydride; sodium iodide; In tetrahydrofuran; water; acetonitrile;

DOI:10.1016/0039-128X(91)90080-F

Reference yield:

spiro<4-cholestene-2,1'-cyclopropane>-3-one (127063-84-7) → 7-(3-oxocholest-4-en-2α-yl)-5-oxa-4-oxoheptanoic acid (134329-94-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / NaI, TMSCl / acetonitrile / 2 h / Ambient temperature

2: 88 percent / NaOH / tetrahydrofuran; H₂O / 9 h / Ambient temperature

3: 43 percent / imidazole, pyridine / 5 h / Heating

With pyridine; 1H-imidazole; sodium hydroxide; chloro-trimethyl-silane; sodium iodide; In tetrahydrofuran; water; acetonitrile;

DOI:10.1016/0039-128X(91)90080-F

upstream raw materials:

succinic acid anhydride

2α-(2'-hydroxyethyl)cholest-4-en-3-one

2-methylenecholest-4-en-3-one

spiro<4-cholestene-2,1'-cyclopropane>-3-one

Refernces