20-hydroxycortisol

Base Information

• Chemical Name: 20-hydroxycortisol
• CAS No.: 2899-95-8
• Molecular Formula: C21H32 O5
• Molecular Weight: 364.482
• Mol file: 2899-95-8.mol

Synonyms:Pregn-4-en-3-one,11b,17,20,21-tetrahydroxy-(7CI,8CI); 11b,17a,20,21-Tetrahydroxy-4-pregnen-3-one;20-Dihydrocortisol

Chemical Property of 20-hydroxycortisol

Chemical Property:

• Melting Point: 120 °C
• Boiling Point: 586.6°Cat760mmHg
• Flash Point: 322.6°C
• PSA: 97.99000
• Density: 1.29g/cm³
• LogP: 1.57340

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 20-hydroxycortisol

There total 8 articles about 20-hydroxycortisol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cortexolone (152-58-9) → HYDROCORTISONE (50-23-7) + Cortisone (53-06-5) + Epicortisol (566-35-8) + 14,17,21-trihydroxy-pregn-4-ene-3,20-dione (595-18-6) + (8S,9S,10R,11S,13S,14S,17R)-17-((R)-1,2-dihydroxyethyl)-11,17-dihydroxy-10,13-dimethyl-6,7,8, 9,10,11,12,13,14,15,16, 17-dodecahydro-1H-cyclopenta[a] phenanthrene-3 (2H)-one (2899-95-8)

Guidance literature:

In ethanol; Product distribution; culture of Cunningamella urvilaria lunata; also other cultures: C_. blakesleeana, Th_. hyalospora or Th_. hiegemella orchidis were used; different times and temperatures of their preparation before reaction;

DOI:10.1007/BF00765389

Reference yield:

HYDROCORTISONE (50-23-7) → Cortisone (53-06-5) + Epicortisol (566-35-8) + (8S,9S,10R,11S,13S,14S,17R)-17-((R)-1,2-dihydroxyethyl)-11,17-dihydroxy-10,13-dimethyl-6,7,8, 9,10,11,12,13,14,15,16, 17-dodecahydro-1H-cyclopenta[a] phenanthrene-3 (2H)-one (2899-95-8)

Guidance literature:

In ethanol; Product distribution; culture of Cunningamella urvilaria lunata; also other cultures: C_. blakesleeana, Th_. hyalospora or Th_. hiegemella orchidis were used; different times and temperatures of their preparation before reaction;

DOI:10.1007/BF00765389

Reference yield:

→ 11β,17,20β,21-Tetrahydroxy-pregn-4-en-3-on (116-58-5,1719-79-5,1921-46-6,2899-95-8)

Guidance literature:

17α,20α,21-Trihydroxypregn-4-en-3-on, Einw. v. Pellicularia; (Nebenprod.: 17α,19,20α,21-tetrahydroxypregn-4-en-3-on);

upstream raw materials:

HYDROCORTISONE

Cortexolone

Downstream raw materials:

adrenosterone

C₂₇H₃₂O₈

C₂₈H₂₈O₈

C₃₀H₃₆O₈

Refernces

• 1、 Garcia-Rodriguez, L. K.,Krasnova, L. A.,Shner, V. F.,Messinova, O. V.. "MICROBIOLOGICAL HYDROXYLATION OF STEROIDS. IV. INFLUENCE OF THERMAL TREATMENT ON THE ENZYME ACTIVITY OF HYDROXYLATING CULTURES". . p. 743 - 745. Retrieved 2007/10/02.