3-Pyridinecarboxylic acid, 6-fluoro-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 3-Pyridinecarboxylic acid, 6-fluoro-, 1,1-dimethylethyl ester
• CAS No.: 676560-01-3
• Molecular Formula: C10H12FNO2
• Molecular Weight: 197.209
• Hs Code.: 2933399990
• Mol file: 676560-01-3.mol

Synonyms:6-fluoronicotinic acid tert-butyl ester;tert-Butyl 6-fluoronicotinate;3-Pyridinecarboxylic acid,6-fluoro-,1,1-dimethylethyl ester;

Chemical Property of 3-Pyridinecarboxylic acid, 6-fluoro-, 1,1-dimethylethyl ester

Chemical Property:

• PSA: 39.19000
• LogP: 2.17600
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

NLT 98% ^*data from raw suppliers

6-Fluoronicotinic acid tert-butyl ester 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarboxylic acid, 6-fluoro-, 1,1-dimethylethyl ester

There total 4 articles about 3-Pyridinecarboxylic acid, 6-fluoro-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-fluoronicotinic acid (403-45-2) + tert-butyl alcohol (75-65-0) → 6-fluoronicotinic acid tert-butyl ester (676560-01-3)

Guidance literature:

With N,N-dimethylformamide di-tert-butyl acetal; for 3h; Heating / reflux;

Reference yield:

6-fluoronicotinic acid (403-45-2) + tert-butyl alcohol (75-65-0) + N,N-dimethylformamide di-tert-butyl acetal (36805-97-7) → 6-fluoronicotinic acid tert-butyl ester (676560-01-3)

Guidance literature:

In hexane; benzene;

Reference yield:

6-fluoronicotinic acid (403-45-2) + N,N-dimethylformamide di-tert-butyl acetal (36805-97-7) → 6-fluoronicotinic acid tert-butyl ester (676560-01-3)

Guidance literature:

In tert-butyl alcohol; benzene; for 3h; Heating;

DOI:10.1021/jm060777o

upstream raw materials:

6-fluoronicotinic acid

N,N-dimethylformamide di-tert-butyl acetal

tert-butyl alcohol

t-butyl nicotinate

Downstream raw materials:

6-(4-amino-4-methyl-cyclohexyloxy)-N,N-dimethyl-nicotinamide

Refernces

• 1、 Madar, David J.,Kopecka, Hana,Pireh, Daisy,Yong, Hong,Pei, Zhonghua,Li, Xiaofeng,Wiedeman, Paul E.,Djuric, Stevan W.,Von Geldern, Thomas W.,Fickes, Michael G.,Bhagavatula, Lakshmi,McDermott, Todd,Wittenberger, Steven,Richards, Steven J.,Longenecker, Kenton L.,Stewart, Kent D.,Lubben, Thomas H.,Ballaron, Stephen J.,Stashko, Michael A.,Long, Michelle A.,Wells, Heidi,Zinker, Bradley A.,Mika, Amanda K.,Beno, David W. A.,Kempf-Grote, Anita J.,Polakowski, James,Segreti, Jason,Reinhart, Glenn A.,Fryer, Ryan M.,Sham, Hing L.,Trevillyan, James M.. "Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl] amino-4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): A very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes". . p. 6416 - 6420. Retrieved 2008/04/18.
• 2、 -. "PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV)". Page 63. . Retrieved 2010/11/30.