3,4-Dimethyl-2,5-dihydrofuran-2-one

Base Information

• Chemical Name: 3,4-Dimethyl-2,5-dihydrofuran-2-one
• CAS No.: 1575-46-8
• Molecular Formula: C6H8 O2
• Molecular Weight: 112.128
• Hs Code.: 2932209090
• Mol file: 1575-46-8.mol

Synonyms:Crotonicacid, 4-hydroxy-2,3-dimethyl-, g-lactone (6CI,7CI); 2,3-Dimethyl-2-butenoic acid g-lactone;2,3-Dimethyl-4-hydroxy-2-butenoic acid lactone;2,3-Dimethyl-4-hydroxy-2-butenoic acid g-lactone; 3,4-Dimethyl-2(5H)-furanone; NSC 362902

Chemical Property of 3,4-Dimethyl-2,5-dihydrofuran-2-one

Chemical Property:

• Vapor Pressure: 0.0897mmHg at 25°C
• Melting Point: 33-34 °C
• Boiling Point: 224.7°Cat760mmHg
• Flash Point: 84.5°C
• PSA: 26.30000
• Density: 1.062g/cm³
• LogP: 0.87960
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99%min ^*data from raw suppliers

3,4-Dimethyl-2(5H)-furanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,4-Dimethyl-2(5H)-furanone is an intermediate in the synthesis of 3,4-Dimethyl-5-pentyl-2-furannonanoic Acid (D477715), an F3 furan fatty acid that exhibits radical-scavenging ability and anti-inflammatory properties.

Technology Process of 3,4-Dimethyl-2,5-dihydrofuran-2-one

There total 27 articles about 3,4-Dimethyl-2,5-dihydrofuran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

carbon monoxide (201230-82-2) + 2-methyl-2,3-butadiene-1-ol (22742-89-8) → 3,4-dimethyl-5H-furan-2-one (1575-46-8)

Guidance literature:

With dodecacarbonyl-triangulo-triruthenium; triethylamine; In 1,4-dioxane; at 100 ℃; for 8h; under 7600 Torr;

DOI:10.1021/jo0350615

Reference yield: 93.0%

(3S*,4R*)-3,4-dimethyl-3-phenylselanyl-γ-butyrolactone → 3,4-dimethyl-5H-furan-2-one (1575-46-8)

Guidance literature:

With sodium periodate; sodium hydrogencarbonate; In methanol; water; at 20 ℃;

DOI:10.1016/S0040-4020(99)00721-8

Reference yield: 88.0%

3,4-dimethyl-5-oxotetrahydrofuran-3-yl acetate (1004788-37-7) → 3,4-dimethyl-5H-furan-2-one (1575-46-8)

Guidance literature:

With p-toluenesulfonic acid monohydrate; at 150 ℃; for 19h;

DOI:10.1002/ejoc.200700656

upstream raw materials:

ethyl 2,3-dimethyl-3-butenoate

ethyl 4-acetyloxy-3-hydroxy-2,3-dimethylbutyrate

5-hydroxy-3,4-dimethylfuran-2(5H)-one

4-hydroxy-3,4-dimethyl-dihydro-furan-2-one

Downstream raw materials:

3,4-dimethylfuran

Refernces

• 1、 Greco, George E.,Gleason, Brittany L.,Lowery, Tiffany A.,Kier, Matthew J.,Hollander, Lisa B.,Gibbs, Shoshanah A.,Worthy, Amanda D.. "Palladium-catalyzed [3+2] cycloaddition of carbon dioxide and trimethylenemethane under mild conditions". . p. 3817 - 3820. Retrieved 2007.
• 2、 Epstein,Sonntag. "-". . p. 791,792. Retrieved 1966.
• 3、 Petroski, Richard J.,Bartelt, Robert J.,Vermillion, Karl. "Synthesis of a dimethylfuran-containing macrolide insect pheromone". experimental part. p. 1389 - 1405. Retrieved 2009/09/26.