Diammonium glycyrrhizinate

Base Information

• Chemical Name: Diammonium glycyrrhizinate
• CAS No.: 79165-06-3
• Deprecated CAS: 31939-42-1
• Molecular Formula: C₄₂H₆₂O₁₆*H₃N
• Molecular Weight: 839.975
• European Community (EC) Number: 258-887-7
• UNII: A9ZZD585U6
• DSSTox Substance ID: DTXSID90229561
• Wikipedia: Glycyrrhizin
• Wikidata: Q27273826
• NCI Thesaurus Code: C102865
• Mol file: 79165-06-3.mol

Synonyms:Acid, Glycyrrhizic;Acid, Glycyrrhizinic;Diammonium Glycyrrhizinate;Dipotassium Glycyrrhizinate;Glycyrrhizate, Zinc;Glycyrrhizic Acid;Glycyrrhizin;Glycyrrhizinate, Diammonium;Glycyrrhizinate, Dipotassium;Glycyrrhizinic Acid;Zinc Glycyrrhizate

Chemical Property of Diammonium glycyrrhizinate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 1021.4 °C at 760 mmHg
• Flash Point: 571.5 °C
• PSA: 273.52000
• LogP: 2.89340
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 10
• Hydrogen Bond Acceptor Count: 18
• Rotatable Bond Count: 7
• Exact Mass: 856.45688409
• Heavy Atom Count: 60
• Complexity: 1730

Purity/Quality:

99.00% ^*data from raw suppliers

Diammonium glycyrrhizinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Biological Agents -> Plant Toxins
• Canonical SMILES: CC1(C2CCC3(C(C2(CCC1OC4C(C(C(C(O4)C(=O)O)O)O)OC5C(C(C(C(O5)C(=O)O)O)O)O)C)C(=O)C=C6C3(CCC7(C6CC(CC7)(C)C(=O)O)C)C)C)C.N.N
• Isomeric SMILES: C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O[C@@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)C(=O)O)O)O)O)C)(C)C(=O)O.N.N
• Recent ClinicalTrials: Magnesium Isoglycyrrhizinate Followed by Diammonium Glycyrrhizinate and Combined With Entecavir in Chronic Hepatitis B
• Recent EU Clinical Trials: A double blind, randomized, placebo-controlled, three-arm, phase II study to investigate the safety and efficacy of oral glycyrrhizin (Glycyron? tablets) for the treatment of gingivitis
• Recent NIPH Clinical Trials: The Effectiveness of Glycyrrhizin in Systemic Sclerosis
• Description: Diammonium Glycyrrhizinate is the diammonium salt of glycyrrhizin and the active constituent in the traditional Chinese medicinal herb Glycyrrhiza uralensis (Chinese liquorice or Gan-Cao) with anti-inflammatory, antioxidant and hepatoprotective properties. Diammonium glycyrrhizinate (DG) is slowly metabolized within the cells into glycyrrhetic acid, which inhibits enzymes that control cortisol metabolism and contributes to this agent's anti-inflammatory effect. Although the exact mechanism of action remains to be fully elucidated, DG may prevent or reduce hepatotoxicity via the scavenging of free radicals. This agent also upregulates the expression of transcription coactivator PGC-1alpha and modulates hepatic enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), superoxide dismutase and glutathion peroxidase.
• Uses: Diammonium glycyrrhizinate (DG) is an ammonium salt preparation of 18-alpha-glycyrrhizin—exhibits antiinflammation, immunomodulation, anti-anaphylaxis, and membranous protection effects.Currently, the family of glycyrrhizin is used in clinical practice as an effective liver protector against most hepatic diseases such as chronic viral hepatitis, drug-induced liver injury, nonalcoholic fatty liver disease, autoimmune hepatitis, and hepatocellular carcinoma.