2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ium-1-ylprop-1-enyl]pyridine;chloride

Base Information

• Chemical Name: 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ium-1-ylprop-1-enyl]pyridine;chloride
• CAS No.: 550-70-9
• Molecular Formula: C19H22 N2 . Cl H
• Molecular Weight: 314.858
• Hs Code.: 2933990090
• European Community (EC) Number: 627-740-2
• Mol file: 550-70-9.mol

Synonyms:2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ium-1-ylprop-1-enyl]pyridine;chloride;6138-79-0

Chemical Property of 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ium-1-ylprop-1-enyl]pyridine;chloride

Chemical Property:

• Melting Point: 116-118 °C
• Boiling Point: 435.4°Cat760mmHg
• Flash Point: 217.1°C
• PSA: 16.13000
• Density: 1.061g/cm³
• LogP: 4.65740
• Storage Temp.: 2-8°C
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 314.1549764
• Heavy Atom Count: 22
• Complexity: 336

Purity/Quality:

99%, ^*data from raw suppliers

trans-Triprolidine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C(=CC[NH+]2CCCC2)C3=CC=CC=N3.[Cl-]
• Isomeric SMILES: CC1=CC=C(C=C1)/C(=C\C[NH+]2CCCC2)/C3=CC=CC=N3.[Cl-]
• Uses: trans-Triprolidine Hydrochloride is a histamine H1 receptor antagonist, which can be used for the prevention of treatment of chronic muscle pain. Triprolidine is an antihistaminic agent with anticholinergic properties. Triprolidine is used to treat and prevent symptoms associated with allergies. Triprolidine is also used in combination with cold medicine to provide relief for flu-like symptoms.
• Therapeutic Function: Antihistaminic

Technology Process of 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ium-1-ylprop-1-enyl]pyridine;chloride

There total 2 articles about 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ium-1-ylprop-1-enyl]pyridine;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

triprolidine (486-12-4,10191-42-1,13573-69-8) → Pro-Actidil (550-70-9)

Guidance literature:

With hydrogenchloride; In water; toluene; at 25 - 30 ℃;

Reference yield:

(Z)-triprolidine (13573-69-8) → Pro-Actidil (550-70-9)

Guidance literature:

(Z)-triprolidine; With methanesulfonic acid; sulfuric acid; at 140 ℃; for 6h;

With hydrogenchloride; In water; butanone; at 0 ℃;

Reference yield:

Pro-Actidil (550-70-9) → hydroxymethyl triprolidine (114576-86-2,121530-42-5)

Guidance literature:

With oxygen; microbial transformsation with cultures of Cunninghamella elegans ATCC 9245 during 24 - 240 h;

DOI:10.1002/jps.2600770316

upstream raw materials:

(Z)-triprolidine

triprolidine

Downstream raw materials:

hydroxymethyl triprolidine

(E)-2-[3-(1-pyrrolodinio)-1-(p-tolyl)-1-propenyl]pyridinium tetrachlorocopper(II)

Refernces

• 1、 -. "A PROCESS FOR THE SYNTHESIS OF (E) -2-[1 - (4 - METHYL PHENYL) -3-(1-PYRRONYL)-1 - PROPENYL] PYRIDINE (TRIPROLIDINE)". Page/Page column 6-7. . Retrieved 2008/06/13.