4-Morpholinobenzoic acid

Base Information

• Chemical Name: 4-Morpholinobenzoic acid
• CAS No.: 7470-38-4
• Molecular Formula: C11H13 N O3
• Molecular Weight: 207.229
• Hs Code.: 2934999090
• Mol file: 7470-38-4.mol

Synonyms:4-(4-Morpholinyl)benzoicacid; 4-Morpholinobenzoic acid; NSC 402784

Chemical Property of 4-Morpholinobenzoic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 278-281 ºC
• Boiling Point: 413.2°Cat760mmHg
• PKA: 4.70±0.10(Predicted)
• Flash Point: 203.7°C
• PSA: 49.77000
• Density: 1.253g/cm³
• LogP: 1.28640
• Storage Temp.: 2-8°C
• Sensitive.: Moisture & Light Sensitive
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

99% ^*data from raw suppliers

4-MorpholinobenzoicAcid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 4-(4-Morpholinyl)benzoic acid, is used as an intermediate in organic synthesis. The water based additive is used in a variety of applications as a heat-sealing and anti-blocking agent.

Technology Process of 4-Morpholinobenzoic acid

There total 11 articles about 4-Morpholinobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.34%

4-morpholinobenzonitrile (10282-31-2) → 4-morpholin-4-yl-benzoic acid (7470-38-4)

Guidance literature:

With sodium hydroxide; for 5h; Reflux;

DOI:10.1016/j.ejmech.2009.04.023

Reference yield: 90.0%

morpholine (110-91-8,99108-56-2) + 4-fluorobenzoic acid ethyl ester (451-46-7) → 4-morpholin-4-yl-benzoic acid (7470-38-4)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In water;

Reference yield: 88.0%

morpholine (110-91-8,99108-56-2) + 4-Bromobenzoic acid (586-76-5) → 4-morpholin-4-yl-benzoic acid (7470-38-4)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 100 ℃; for 12h;

DOI:10.1002/aoc.3906

upstream raw materials:

4-morpholinobenzonitrile

2,2,2-trifluoro-1-(4-morpholin-4-yl-phenyl)-ethanone

2,2,2-trifluoro-1-(4-fluorophenyl)ethanone

4-fluorobenzonitrile

Downstream raw materials:

C₃₆H₄₄N₆O₇

N-(2-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-ethyl)-4-morpholin-4-yl-benzamide

Refernces

• 1、 Wei, Manman,Peng, Xia,Xing, Li,Dai, Yang,Huang, Ruimin,Geng, Meiyu,Zhang, Ao,Ai, Jing,Song, Zilan. "Design, synthesis and biological evaluation of a series of novel 2-benzamide-4-(6-oxy-N-methyl-1-naphthamide)-pyridine derivatives as potent fibroblast growth factor receptor (FGFR) inhibitors". . p. 9 - 28. Retrieved 2018/05/28.
• 2、 Raparti, Vyankatesh,Chitre, Trupti,Bothara, Kailas,Kumar, Vanaja,Dangre, Sudarshan,Khachane, Chetan,Gore, Suraj,Deshmane, Bhavana. "Novel 4-(morpholin-4-yl)-N′-(arylidene)benzohydrazides: Synthesis, antimycobacterial activity and QSAR investigations". experimental part. p. 3954 - 3960. Retrieved 2009/12/04.