5-Phospho-D-ribosylamine

Base Information

• Chemical Name: 5-Phospho-D-ribosylamine
• CAS No.: 14050-66-9
• Deprecated CAS: 113875-42-6
• Molecular Formula: C5H12 N O7 P
• Molecular Weight: 273.09
• DSSTox Substance ID: DTXSID10903977
• Wikipedia: Phosphoribosylamine
• Metabolomics Workbench ID: 50849
• Mol file: 14050-66-9.mol

Synonyms:phosphoribosylamine

Chemical Property of 5-Phospho-D-ribosylamine

Chemical Property:

• Vapor Pressure: 4.69E-14mmHg at 25°C
• Boiling Point: 543°Cat760mmHg
• Flash Point: 282.2°C
• PSA: 152.28000
• Density: 1.791g/cm³
• LogP: -1.79860
• XLogP3: -6.2
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 3
• Exact Mass: 229.03513872
• Heavy Atom Count: 14
• Complexity: 242

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C1C(C(C(O1)N)O)O)OP(=O)(O)O
• Isomeric SMILES: C([C@@H]1[C@H]([C@H](C(O1)N)O)O)OP(=O)(O)O

Technology Process of 5-Phospho-D-ribosylamine

There total 4 articles about 5-Phospho-D-ribosylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

α,β-D-ribofuranose-5-phophate disodium salt (108321-99-9,150713-51-2) → phosphoribosylamine (14050-66-9)

Guidance literature:

With ammonia; In ethylene glycol; at 5 ℃; for 15h;

DOI:10.1021/ja00313a045

Reference yield:

adenosine 5'-monophosphate (47287-36-5,119923-66-9) → phosphoribosylamine (14050-66-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / 1.) H(+), H₂O; 2.) 10N NaOH / 1.) 100 deg C, 6 min; 2.) 0 deg C

2: NH₃ / ethane-1,2-diol / 15 h / 5 °C

With sodium hydroxide; ammonia; water; hydrogen cation; In ethylene glycol;

DOI:10.1021/ja00313a045

Reference yield:

D-ribose 5-phosphate (3615-55-2,7591-07-3,13137-52-5,66768-39-6,69881-36-3,69881-39-6,136376-80-2,136376-83-5,136376-85-7,136376-88-0,136376-89-1,4300-28-1) → 5-phosphoribosylamine (14050-66-9)

Guidance literature:

With ammonia;

upstream raw materials:

D-ribose 5-phosphate

ammonia

α,β-D-ribofuranose-5-phophate disodium salt

adenosine 5'-monophosphate

Downstream raw materials:

nicotinamide mononucleotide

α-nicotinamide mononucleotide

2,4-Dinitroanilin

Refernces