Glaziovine

Base Information

• Chemical Name: Glaziovine
• CAS No.: 17127-48-9
• Molecular Formula: C18H19 N O3
• Molecular Weight: 297.354
• Mol file: 17127-48-9.mol

Synonyms:Glaziovine,(?à)- (8CI); Spiro[2,5-cyclohexadiene-1,7'(1'H)-cyclopent[ij]isoquinolin]-4-one,2',3',8',8'a-tetrahydro-6'-hydroxy-5'-methoxy-1'-methyl-, (?à)-; (?à)-Glaziovine; NSC 146052

Chemical Property of Glaziovine

Chemical Property:

• Vapor Pressure: 1.74E-09mmHg at 25°C
• Melting Point: 227-228 °C
• Boiling Point: 470.8°Cat760mmHg
• PKA: 9.76±0.20(Predicted)
• Flash Point: 238.5°C
• PSA: 49.77000
• Density: 1.33g/cm³
• LogP: 2.20430

Purity/Quality:

99%, ^*data from raw suppliers

GLAZIOVINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Therapeutic Function: Tranquilizer

Technology Process of Glaziovine

There total 3 articles about Glaziovine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-methylcoclaurine (1472-62-4) → 1,2-didehydrocoripallinium ion (72142-82-6) + N-methylcrotsparine (17127-48-9) + (4-hydroxyphenyl)methanol (623-05-2) + 2-Methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-1,10,11-triol (72142-83-7)

Guidance literature:

With dihydrogen peroxide; In methanol; water; for 14h; Further byproducts given; Ambient temperature; ascorbate oxidase from Cucurbita pepo medullosa L_., phosphate buffer pH 7.0;

Reference yield:

N-methylcoclaurine (1472-62-4) → N-methylcrotsparine (17127-48-9) + 6-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-ol (450-14-6) + (4-hydroxyphenyl)methanol (623-05-2) + 2-Methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-1,10,11-triol (72142-83-7)

Guidance literature:

With dihydrogen peroxide; In methanol; water; for 14h; Further byproducts given; Ambient temperature; ascorbate oxidase from Cucurbita pepo medullosa L_., phosphate buffer pH 7.0;

Reference yield:

N-methylcoclaurine (1472-62-4) → 1,2-didehydrocoripallinium ion (72142-82-6) + N-methylcrotsparine (17127-48-9) + 6-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-ol (450-14-6) + (4-hydroxyphenyl)methanol (623-05-2) + 2-Methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-1,10,11-triol (72142-83-7)

Guidance literature:

With dihydrogen peroxide; In methanol; water; for 14h; Product distribution; Ambient temperature; ascorbate oxidase from Cucurbita pepo medullosa L_. or peroxidase from Nelumbo nucifera Gaertn_.; phosphate buffer pH 7.0;

upstream raw materials:

N-methylcoclaurine

Refernces