Cyclobutanepropanoic acid, a-amino-b-oxo-, phenylmethyl ester, hydrochloride

Base Information

• Chemical Name: Cyclobutanepropanoic acid, a-amino-b-oxo-, phenylmethyl ester, hydrochloride
• CAS No.: 681807-14-7
• Molecular Formula: C14H17NO3.ClH
• Molecular Weight: 283.755
• Mol file: 681807-14-7.mol

Synonyms:

Chemical Property of Cyclobutanepropanoic acid, a-amino-b-oxo-, phenylmethyl ester, hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclobutanepropanoic acid, a-amino-b-oxo-, phenylmethyl ester, hydrochloride

There total 1 articles about Cyclobutanepropanoic acid, a-amino-b-oxo-, phenylmethyl ester, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl 2-tert-butoxycarbonylamino-3-cyclobutyl-3-oxopropionate (1140909-07-4) → benzyl 2-amino-3-cyclobutyl-3-oxopropionate hydrochloride (681807-14-7)

Guidance literature:

With hydrogenchloride; water; In 1,4-dioxane; at 20 ℃;

DOI:10.1016/j.tetasy.2008.12.024

Reference yield:

benzoyl chloride (98-88-4) + benzyl 2-amino-3-cyclobutyl-3-oxopropionate hydrochloride (681807-14-7) → benzyl (2S,3S)-2-benzoylamino-3-cyclobutyl-3-hydroxypropionate + benzyl (2R,3R)-2-benzoylamino-3-cyclobutyl-3-hydroxypropionate

Guidance literature:

benzyl 2-amino-3-cyclobutyl-3-oxopropionate hydrochloride; With [RuCl₂(S)-BINAP](dmf)n; hydrogen; In propan-1-ol; at 50 ℃; for 48h; under 76000 Torr;

benzoyl chloride; With triethylamine; In tetrahydrofuran; at 20 ℃; for 1h; Title compound not separated from byproducts;

DOI:10.1002/anie.200353072

Reference yield:

benzyl 2-amino-3-cyclobutyl-3-oxopropionate hydrochloride (681807-14-7) → 2-amino-3-cyclobutyl-3-hydroxy-propionic acid benzyl ester; hydrochloride + (2S,3S)-2-Amino-3-cyclobutyl-3-hydroxy-propionic acid benzyl ester; hydrochloride + (2R,3R)-2-Amino-3-cyclobutyl-3-hydroxy-propionic acid benzyl ester; hydrochloride

Guidance literature:

With [RuCl₂(S)-BINAP](dmf)n; hydrogen; In propan-1-ol; at 50 ℃; for 48h; under 76000 Torr; Title compound not separated from byproducts;

DOI:10.1002/anie.200353072

upstream raw materials:

benzyl 2-tert-butoxycarbonylamino-3-cyclobutyl-3-oxopropionate

Refernces