4-chloro-6-nitro-Cinnoline

Base Information

• Chemical Name: 4-chloro-6-nitro-Cinnoline
• CAS No.: 68211-17-6
• Molecular Formula: C8H4ClN3O2
• Molecular Weight: 209.592
• Mol file: 68211-17-6.mol

Synonyms:4-Chlor-6-nitro-cinnolin;

Chemical Property of 4-chloro-6-nitro-Cinnoline

Chemical Property:

• PSA: 71.60000
• LogP: 2.71460

Purity/Quality:

≥99% ^*data from raw suppliers

4-Chloro-6-nitrocinnoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-chloro-6-nitro-Cinnoline

There total 8 articles about 4-chloro-6-nitro-Cinnoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxy-6-nitrocinnoline (7387-19-1) → 4-chloro-6-nitrocinnoline (68211-17-6)

Guidance literature:

With thionyl chloride; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

6-nitro-1H-cinnolin-4-one (86222-55-1) → 4-chloro-6-nitrocinnoline (68211-17-6)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate;

DOI:10.1039/jr9450000512

Reference yield:

4(1H)-cinnolon (18514-84-6) → 4-chloro-6-nitrocinnoline (68211-17-6)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous HNO₃; H₂SO₄

2: PCl₅; POCl₃

With phosphorus pentachloride; sulfuric acid; nitric acid; trichlorophosphate;

DOI:10.1039/jr9450000512

upstream raw materials:

6-nitro-1H-cinnolin-4-one

4(1H)-cinnolon

4-oxo-1,4-dihydrocinnoline-3-carboxylic acid

2-ethynyl-1-nitrobenzene

Downstream raw materials:

4-Methoxy-6-nitro-cinnolin

6-nitrocinnolin-4-ylamine

Refernces