3,3',4,4'-Tetramethoxybenzophenone

Base Information

• Chemical Name: 3,3',4,4'-Tetramethoxybenzophenone
• CAS No.: 4131-03-7
• Molecular Formula: C17H18O5
• Molecular Weight: 302.327
• Hs Code.: 2914509090
• Mol file: 4131-03-7.mol

Synonyms:3,4-dimethoxy-3,'4'-dimethoxybenzophenone;bis(3,4-diMethoxyphenyl)Methanone;3,4,3',4'-Tetramethoxy-benzophenon;3,4,3',4'-tetramethoxy-benzophenone;Methanone, bis(3,4-dimethoxyphenyl)-;

Chemical Property of 3,3',4,4'-Tetramethoxybenzophenone

Chemical Property:

• Vapor Pressure: 1.62E-08mmHg at 25°C
• Boiling Point: 456.4°Cat760mmHg
• Flash Point: 202°C
• PSA: 53.99000
• Density: 1.147g/cm³
• LogP: 2.95200

Purity/Quality:

99%min ^*data from raw suppliers

Bis(3,4-dimethoxyphenyl)methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,3',4,4'-Tetramethoxybenzophenone

There total 40 articles about 3,3',4,4'-Tetramethoxybenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3,3',4,4'-tetramethoxybenzhydrole (74084-26-7) → bis(3,4-dimethoxyphenyl)methanone (4131-03-7)

Guidance literature:

With dipyridinium dichromate; In dichloromethane; at 0 - 15 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c3ob41672k

Reference yield: 92.0%

diethyl (bis(3,4-dimethoxyphenyl)methyl)phosphonate → bis(3,4-dimethoxyphenyl)methanone (4131-03-7)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 14h;

DOI:10.1021/acs.joc.9b00668

Reference yield: 86.0%

1,2-dimethoxybenzene (91-16-7) + Veratric acid (93-07-2) → bis(3,4-dimethoxyphenyl)methanone (4131-03-7)

Guidance literature:

With polyphosphoric acid; at 80 ℃; for 2h;

DOI:10.1002/ardp.201100373

upstream raw materials:

oxalyl dichloride

1,2-dimethoxybenzene

1,1-[bis(3,4-dimethoxyphenyl)]ethane

2-(3,4-Dimethoxy-benzoyl)-4,5-dimethoxy-benzoic acid

Downstream raw materials:

3,3-bis-(3,4-dimethoxy-phenyl)-acrylic acid

3-(3,4-dimethoxyphenyl)-5,6-dimethoxy-2-methyl-1H-inden-1-one

4.4-Bis-<3.4-dimethoxy-phenyl>-3-tert-butyloxycarbonyl-buten-(3)-saeure-(1)

3,3-bis(3,4-dimethoxyphenyl)propenal

Refernces

• 1、 -. "A kind of LSD1 inhibitors and use thereof". Paragraph 0019; 0022; 0023. . Retrieved 2019/07/04.
• 2、 Prasad, Sure Siva,Singh, DIleep Kumar,Kim, Ikyon. "One-Pot, Three-Component Approach to Diarylmethylphosphonates: A Direct Entry to Polycyclic Aromatic Systems". . p. 6323 - 6336. Retrieved 2019/05/24.