2,3-Dihydro-2,2,4,6-tetramethylpyridine

Base Information

• Chemical Name: 2,3-Dihydro-2,2,4,6-tetramethylpyridine
• CAS No.: 63681-01-6
• Molecular Formula: C9H15N
• Molecular Weight: 137.225
• European Community (EC) Number: 627-060-6
• DSSTox Substance ID: DTXSID5073589
• Nikkaji Number: J1.622.948B
• Wikidata: Q82002042
• Mol file: 63681-01-6.mol

Synonyms:63681-01-6;2,3-Dihydro-2,2,4,6-tetramethylpyridine;BRN 0108600;2,2,4,6-tetramethyl-2,3-dihydropyridine;SCHEMBL689728;DTXSID5073589;Pyridine, 2,3-dihydro-2,2,4,6-tetramethyl-;4-20-00-02169 (Beilstein Handbook Reference)

Chemical Property of 2,3-Dihydro-2,2,4,6-tetramethylpyridine

Chemical Property:

• Vapor Pressure: 2.02mmHg at 25°C
• Refractive Index: 1.5000 (estimate)
• Boiling Point: 169.7°C at 760 mmHg
• Flash Point: 47.7°C
• PSA: 12.36000
• Density: 0.88g/cm³
• LogP: 2.01150
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 137.120449483
• Heavy Atom Count: 10
• Complexity: 197

Purity/Quality:

99% ^*data from raw suppliers

2,2,4,6-tetramethyl-1,2-dihydropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=CC(=NC(C1)(C)C)C

Technology Process of 2,3-Dihydro-2,2,4,6-tetramethylpyridine

There total 4 articles about 2,3-Dihydro-2,2,4,6-tetramethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dimethylpentane-2,4-diol (24892-49-7,139687-48-2) + acetonitrile (75-05-8,26809-02-9) → 2,2,4,6-tetramethyl-2,3-dihydropyridine (63681-01-6) + N-tert-butylacetamide (762-84-5)

Guidance literature:

With sulfuric acid;

DOI:10.1021/jo01106a026

Reference yield:

acetone (67-64-1) → 2,2,4,6-tetramethyl-2,3-dihydropyridine (63681-01-6) + 2,2,4,4,6-pentamethyl-2,3,4,5,tetrahydropyrimidine (556-72-9)

Guidance literature:

With ammonium hydroxide; water; at 65 ℃; for 6h;

DOI:10.1016/j.molcata.2014.06.023

Reference yield:

acetone (67-64-1) → 2,2,4,6-tetramethyl-2,3-dihydropyridine (63681-01-6) + 2,2,6,6-Tetramethyl-4-piperidone (826-36-8) + 2,2,4,4,6-pentamethyl-2,3,4,5,tetrahydropyrimidine (556-72-9)

Guidance literature:

With ammonium hydroxide; water; at 25 ℃; for 72h; Reagent/catalyst;

DOI:10.1016/j.molcata.2014.06.023

upstream raw materials:

2,4-dimethylpentane-2,4-diol

acetonitrile

acetone

Downstream raw materials:

2,4,6-trimethyl-pyridine

Refernces

• 1、 Gliozzi, Gherardo,Frattini, Lucia,Righi, Paolo,Cavani, Fabrizio. "Towards a more sustainable production of triacetoneamine with heterogeneous catalysis". . p. 325 - 332. Retrieved 2014/08/18.