Zolazepam

Base Information

• Chemical Name: Zolazepam
• CAS No.: 31352-82-6
• Molecular Formula: C15H15 F N4 O
• Molecular Weight: 286.309
• European Community (EC) Number: 608-606-2
• UNII: G1R474U58U
• DSSTox Substance ID: DTXSID30185278
• Nikkaji Number: J20.555I
• Wikipedia: Zolazepam
• Wikidata: Q4024647
• NCI Thesaurus Code: C84252
• Metabolomics Workbench ID: 152713
• ChEMBL ID: CHEMBL2111144
• Mol file: 31352-82-6.mol

Synonyms:CI 716;CI-716;CI716;Flupyrazapon;Flupyrazopon;Hydrochloride, Zolazepam;Zolasepam;Zolazepam;Zolazepam Hydrochloride

Chemical Property of Zolazepam

Chemical Property:

• Vapor Pressure: 2.2E-10mmHg at 25°C
• Melting Point: 183-185 °C(Solv: methanol (67-56-1); ethyl ether (60-29-7))
• Boiling Point: 506.6°Cat760mmHg
• PKA: 1.85±0.20(Predicted)
• Flash Point: 260.2°C
• PSA: 50.49000
• Density: 1.31g/cm³
• LogP: 1.18200
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 286.12298928
• Heavy Atom Count: 21
• Complexity: 455

Purity/Quality:

99%, ^*data from raw suppliers

ZOLAZEPAM 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NN(C2=C1C(=NCC(=O)N2C)C3=CC=CC=C3F)C
• Uses: A sedative and anesthetic

Technology Process of Zolazepam

There total 2 articles about Zolazepam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(N-methylaminoacetamido)-1,3-dimethyl-4-o-fluorobenzoylpyrazole → Zolazepam (31352-82-6)

Guidance literature:

In water; at 27 ℃; equilibrium reaction; intrinsic ring closure constant K*'; effect of pH (3.70 - 6.04);

DOI:10.1002/jps.2600700633

Reference yield:

→ Zolazepam (31352-82-6)

Guidance literature:

Pyrazol 23 H2 Pd/C;

DOI:10.1021/jm00222a005

Refernces

• 1、 DeWald,Lobbestael,Butler. "Pyrazolodiazepines. 2. 4-Aryl-1,3-dialkyl-6,8-dihydropyrazolo[3,4-e][1,4]diazepin-7(1H)-ones as antianxiety and anticonvulsant agents". . p. 1562 - 1569. Retrieved 2007/10/05.