4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 26892-90-0
• Molecular Formula: C12H11NO3
• Molecular Weight: 217.224
• Hs Code.: 2933499090
• Mol file: 26892-90-0.mol

Synonyms:3-Ethoxycarbonyl-4-quinolinol;4-Hydroxyquinoline-3-carboxylic acid ethyl ester;Ethyl 4-hydroxyquinoline-3-carboxylate;NSC 4345;4-Oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester;3-Quinolinecarboxylic acid, 1,4-dihydro-4-oxo-, ethyl ester;

Chemical Property of 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Appearance/Colour: Off-white Powder
• Vapor Pressure: 6.92E-05mmHg at 25°C
• Melting Point: 270oC
• Refractive Index: 1.569
• Boiling Point: 343.7 °C at 760 mmHg
• PKA: 2.62±0.50(Predicted)
• Flash Point: 161.7 °C
• PSA: 59.42000
• Density: 1.246 g/cm³
• LogP: 2.11710

Purity/Quality:

98% ^*data from raw suppliers

4-Hydroxyquinoline-3-carboxylic acid ethyl ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

There total 21 articles about 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

diethyl (anilinomethylene)malonate (54535-22-7) → ethyl 4-hydroxy-3-quinolinecarboxylate (26892-90-0)

Guidance literature:

In 1,2-dibenzylbenzene;

Reference yield: 86.0%

diethyl (ethoxymethylene)malonate (40516-46-9) + aniline (62-53-3) → ethyl 4-hydroxy-3-quinolinecarboxylate (26892-90-0)

Guidance literature:

In ethanol; for 3.5h; Reflux;

Reference yield: 76.0%

aniline (62-53-3) + diethyl 2-ethoxymethylenemalonate (87-13-8) → ethyl 4-hydroxy-3-quinolinecarboxylate (26892-90-0)

Guidance literature:

In ethanol; at 100 - 200 ℃; for 3h;

upstream raw materials:

diphenylether

biphenyl

diethyl (anilinomethylene)malonate

4-hydroxy-3-quinoline carboxylic acid

Downstream raw materials:

1,4-dihydro-1-methyl-4-oxoquinoline-3-carboxylic acid

4-hydroxy-3-quinoline carboxylic acid

ethyl 4-chloroquinoline-3-carboxylate

2-(4-chlorophenyl)-pyrazolo[4,3-c]quinolin-3-one

Refernces

• 1、 Simpson. "-". . p. 1035. Retrieved 1946.
• 2、 -. "Synthesis method and device of 4 -hydroxyquinoline -3 - formic acid". Paragraph 0091-0095; 0112. . Retrieved 2021/09/21.
• 3、 -. "METHODS OF TREATMENT FOR CYSTIC FIBROSIS". Paragraph 00227. . Retrieved 2020/12/11.