2-CHLORO-2-ETHOXYACETIC ACID ETHYL ESTER

Base Information

• Chemical Name: 2-CHLORO-2-ETHOXYACETIC ACID ETHYL ESTER
• CAS No.: 34006-60-5
• Molecular Formula: C6H11ClO3
• Molecular Weight: 166.605
• Hs Code.: 29189990
• DSSTox Substance ID: DTXSID20955583
• Mol file: 34006-60-5.mol

Synonyms:Aceticacid, chloroethoxy-, ethyl ester (6CI,7CI,8CI,9CI);2-Chloro-2-ethoxyaceticacid ethyl ester;Ethyl 2-chloro-2-ethoxyacetate;Ethyl 2-(2-chloroethoxy) acetate;

Chemical Property of 2-CHLORO-2-ETHOXYACETIC ACID ETHYL ESTER

Chemical Property:

• Appearance/Colour: colourless liquid
• Vapor Pressure: 0.202mmHg at 25°C
• Refractive Index: 1.4307
• Boiling Point: 209.5 °C at 760 mmHg
• Flash Point: 84 °C
• PSA: 35.53000
• Density: 1.117 g/cm³
• LogP: 1.15090
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 166.0396719
• Heavy Atom Count: 10
• Complexity: 105

Purity/Quality:

99% ^*data from raw suppliers

Ethyl chloro(ethoxy)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)COC(C)Cl

Technology Process of 2-CHLORO-2-ETHOXYACETIC ACID ETHYL ESTER

There total 9 articles about 2-CHLORO-2-ETHOXYACETIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Ethyl diethoxyacetate (6065-82-3) → ethyl 2-chloro-2-ethoxyacetate (34006-60-5)

Guidance literature:

With iodine; acetyl chloride; at 50 ℃; for 22h;

Reference yield: 100.0%

acetyl chloride (75-36-5) + Ethyl diethoxyacetate (6065-82-3) → ethyl 2-chloro-2-ethoxyacetate (34006-60-5)

Guidance literature:

With iodine;

Reference yield:

→ ethyl 2-chloro-2-ethoxyacetate (34006-60-5)

Guidance literature:

With thionyl chloride; at 80 ℃;

upstream raw materials:

2,2-diethoxy acetic acid

Ethyl diethoxyacetate

diazoacetic acid ethyl ester

diethyl ether

Downstream raw materials:

ethyl p-methoxyphenylacetate

ethyl 2-hydroxy-2-(4-methoxyphenyl)acetate

ethyl 2-[2-[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluorophenoxy]phenoxy]-2-ethoxyacetate

(RS)-ethoxy-[3-(4-methoxy-phenyl)-pyrazol-1-yl]-acetic acid ethyl ester

Refernces

• 1、 -. "CHROMOIONOPHORE AND METHOD OF DETERMINING CALCIUM IONS". . . Retrieved 2008/06/13.
• 2、 Deussen, Heinz-Josef,Zundel, Magali,Valdois, Marine,Lehmann, Soren Vig,Weil, Volker,Mailand Hjort, Carsten,stergaard, Peter Rahbek,Marcussen, Erik,Ebdrup, Soren. "Process development on the enantioselective enzymatic hydrolysis of S-ethyl 2-ethoxy-3-(4-hydroxyphenyl)propanoate". . p. 82 - 88. Retrieved 2013/09/05.