o-Tolylhydrazine

Base Information

• Chemical Name: o-Tolylhydrazine
• CAS No.: 529-27-1
• Molecular Formula: C7H10N2
• Molecular Weight: 122.17
• Hs Code.: 2928000090
• European Community (EC) Number: 208-455-9
• UNII: 9FLY8GU8UR
• DSSTox Substance ID: DTXSID40200941
• Nikkaji Number: J134.590G
• Wikidata: Q83074131
• Mol file: 529-27-1.mol

Synonyms:o-Tolylhydrazine;(2-Methylphenyl)hydrazine;529-27-1;1-(2-Methylphenyl)hydrazine;2-methylphenylhydrazine;Hydrazine, (2-methylphenyl)-;o-Tolylhydrazinehydrochloride;EINECS 208-455-9;(2-Methylphenyl)-Hydrazine;1-o-tolylhydrazine hydrochloride;tolylhydrazine;o-tolylhydrazin;2-Tolylhydrazine;1-o-tolylhydrazine;2methylphenylhydrazine;o-Methylphenylhydrazine;2-methylphenyl hydrazine;9FLY8GU8UR;SCHEMBL787;1-(2-Methylphenyl)hydrazine #;DTXSID40200941;BBL007626;MFCD00044584;STK378588;AKOS000268844;SB75422;VS-01697;A8746;BB 0219955;FT-0738226;A18849;4-FORMYL-2-METHOXYPHENYL3,4,5-TRIMETHOXYBENZOATE

Chemical Property of o-Tolylhydrazine

Chemical Property:

• Vapor Pressure: 0.0766mmHg at 25°C
• Melting Point: 163-165 °C
• Boiling Point: 227.7°Cat760mmHg
• PKA: 5.33±0.10(Predicted)
• Flash Point: 104.1°C
• PSA: 38.05000
• Density: 1.087g/cm³
• LogP: 2.05390
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 122.084398327
• Heavy Atom Count: 9
• Complexity: 83

Purity/Quality:

98%min ^*data from raw suppliers

(2-methylphenyl)hydrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CC=C1NN

Technology Process of o-Tolylhydrazine

There total 9 articles about o-Tolylhydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

o-toluidine (95-53-4) → 2-methylphenylhydrazine (529-27-1)

Guidance literature:

Multi-step reaction with 2 steps

1: HNO₂, HCl

2: SnCl₂

With hydrogenchloride; cis-nitrous acid; tin(ll) chloride;

Reference yield:

2-methylchlorobenzene (95-49-8) → 2-methylphenylhydrazine (529-27-1)

Guidance literature:

With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; N-[2-(di(1-adamantyl)phosphino)phenyl]morpholine; hydrazine hydrate; sodium t-butanolate; In toluene; at 90 ℃; for 1.5h; Inert atmosphere; Glovebox;

DOI:10.1016/j.bmcl.2015.11.022

Reference yield:

ortho-methylphenyl iodide (615-37-2) → 2-methylphenylhydrazine (529-27-1)

Guidance literature:

With potassium phosphate; copper(l) iodide; hydrazine hydrate; at 120 ℃; for 6h; Sealed tube; Inert atmosphere;

DOI:10.1016/j.tet.2012.11.014

upstream raw materials:

2-methylbenzene diazonium

o-toluene-diazonium chloride

hydrogenchloride

o-toluidine

Downstream raw materials:

cyclohexanone-o-tolylhydrazone

1-o-tolyl-4,5-dihydro-1H-pyrazol-3-ylamine

isobutyric acid 2-(2-methylphenyl)hydrazide

3-methyl-butan-2-one-o-tolylhydrazone

Refernces

• 1、 Hosseini-Sarvari, Mona,Koohgard, Mehdi. "Visible-light-mediated phosphonylation reaction: formation of phosphonates from alkyl/arylhydrazines and trialkylphosphites using zinc phthalocyanine". supporting information. p. 5905 - 5911. Retrieved 2021/07/12.
• 2、 -. "Preparation method of 2-methyl phenylhydrazine phosphate". Paragraph 0020; 0022; 0024; 0030; 0032; 0034; 0037-0044. . Retrieved 2018/07/30.