2-(1-(2-Methylphenyl))ethenylpyridine

Base Information

• Chemical Name: 2-(1-(2-Methylphenyl))ethenylpyridine
• CAS No.: 74309-54-9
• Molecular Formula: C14H13N
• Molecular Weight: 195.264
• DSSTox Substance ID: DTXSID90995830
• Wikidata: Q82987430
• Mol file: 74309-54-9.mol

Synonyms:2-(1-(2-Methylphenyl))ethenylpyridine;74309-54-9;2-[1-(2-methylphenyl)]ethenylpyridine;2-[1-(2-methylphenyl)ethenyl]pyridine;DTXSID90995830

Chemical Property of 2-(1-(2-Methylphenyl))ethenylpyridine

Chemical Property:

• Vapor Pressure: 0.00173mmHg at 25°C
• Refractive Index: 1.573
• Boiling Point: 302.9 °C at 760 mmHg
• PKA: 3.96±0.10(Predicted)
• Flash Point: 126.3 °C
• PSA: 12.89000
• Density: 1.02 g/cm³
• LogP: 3.45150
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 195.104799419
• Heavy Atom Count: 15
• Complexity: 221

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CC=C1C(=C)C2=CC=CC=N2

Technology Process of 2-(1-(2-Methylphenyl))ethenylpyridine

There total 8 articles about 2-(1-(2-Methylphenyl))ethenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-(pyridin-2-yl)-1-(o-tolyl)ethanol → 2-[1-(2-tolyl)-vinyl]pyridine (74309-54-9)

Guidance literature:

With sulfuric acid; In water; at 100 ℃; for 0.25h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b01746

Reference yield: 78.0%

(pyridin-2-yl)(o-tolyl)methanone (54523-78-3) + Methyltriphenylphosphonium bromide (1779-49-3) → 2-[1-(2-tolyl)-vinyl]pyridine (74309-54-9)

Guidance literature:

Methyltriphenylphosphonium bromide; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 1h; Schlenk technique; Inert atmosphere;

(pyridin-2-yl)(o-tolyl)methanone; In tetrahydrofuran; at 50 ℃; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.7b02262

Reference yield: 69.0%

2-[(2-methylphenyl)methyl]pyridine (36995-45-6) + N,N-dimethyl acetamide (127-19-5,116057-81-9) → 2-[1-(2-tolyl)-vinyl]pyridine (74309-54-9)

Guidance literature:

With sodium persulfate; copper(II) acetate monohydrate; at 120 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ol500655k

upstream raw materials:

(pyridin-2-yl)(o-tolyl)methanone

2-[(2-methylphenyl)methyl]pyridine

N,N-dimethyl acetamide

2-acetylpyridine

Refernces

• 1、 Yang, Hailong,Wang, Erfei,Yang, Ping,Lv, Hui,Zhang, Xumu. "Pyridine-directed asymmetric hydrogenation of 1 1-diarylalkenes". supporting information. p. 5062 - 5065. Retrieved 2017/11/07.
• 2、 Chaitanya, Manthena,Anbarasan, Pazhamalai. "Rhodium-Catalyzed Cyanation of C(sp2)-H Bond of Alkenes". supporting information. p. 3766 - 3769. Retrieved 2015/08/18.