N2-acetyl-2'-deoxyguanosine

Base Information

• Chemical Name: N2-acetyl-2'-deoxyguanosine
• CAS No.: 4318-06-3
• Molecular Formula: C₁₂H₁₅N₅O₅
• Molecular Weight: 309.282
• Mol file: 4318-06-3.mol

Synonyms:Acetamide,N-[9-(2-deoxy-b-D-erythro-pentofuranosyl)-1,6-dihydro-6-oxo-9H-purin-2-yl]-(8CI); N2-Acetyl-2'-deoxyguanosine

Chemical Property of N2-acetyl-2'-deoxyguanosine

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 142.36000
• Density: 1.87g/cm³
• LogP: -1.20830

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N2-acetyl-2'-deoxyguanosine

There total 5 articles about N2-acetyl-2'-deoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

N-(6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide (19962-37-9) + 2'-Deoxyguanosine (961-07-9) → C12H15N5O5 (1061382-93-1) + N2-acetyldeoxyguanosine (4318-06-3)

Guidance literature:

With purine nucleoside phosphorylase; potassium phosphate buffer; at 50 ℃; pH=7.0;

DOI:10.1080/15257770701506343

Reference yield: 70.0%

2-(acetylamino)-9-(3,5-di-O-acetyl-2-deoxy-β-D-erythro-pentofuranosyl)-1,9-dihydro-6H-purin-6-one (4318-05-2) → N2-acetyldeoxyguanosine (4318-06-3)

Guidance literature:

With methanol; sodium methylate; at 0 ℃; for 0.0833333h;

DOI:10.1016/0040-4020(95)01043-2

Reference yield: 55.0%

N-(6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide (19962-37-9) + thymidine (50-89-5,28854-96-8,3545-96-8,50-88-4) → C12H15N5O5 (1061382-93-1) + N2-acetyldeoxyguanosine (4318-06-3)

Guidance literature:

With purine nucleoside phosphorylase; potassium phosphate buffer; at 50 ℃; pH=7.0;

DOI:10.1080/15257770701506343

upstream raw materials:

N-(6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide

2'-deoxyuridine

2-(acetylamino)-9-(3,5-di-O-acetyl-2-deoxy-β-D-erythro-pentofuranosyl)-1,9-dihydro-6H-purin-6-one

2'-Deoxyguanosine

Downstream raw materials:

5'-dimethoxytrityl-N²-acetyldeoxyguanosine

O⁶<2-methoxy-6-chloro-9-(ω-pentylamino)>-acridine-5'-O-dimethoxytrityl-3'-O-(tert-butyldimethylsilyl)-N²-acetyldeoxyguanosine

O⁶-(2,4,6-triisopropylbenzenesulfonyl)-5'-O-dimethoxytrityl-3'-O-(tert-butyldimethylsilyl)-N²-acetyldeoxyguanosine

O⁶<2-methoxy-6-chloro-9-(ω-pentylamino)>-acridine-5'-O-dimethoxytrityl-N²-acetyldeoxyguanosine

Refernces

• 1、 Raynaud, Francoise,Asseline, Ulysse,Roig, Victoria,Thuong, Nguyen Thanh. "Synthesis and characterization of O6-modified deoxyguanosine-containing oligodeoxyribonucleotides for triple-helix formation". . p. 2047 - 2064. Retrieved 2007/10/03.