Prilosec OTC

Base Information

• Chemical Name: Prilosec OTC
• CAS No.: 95382-33-5
• Molecular Formula: C₃₄H₃₆MgN₆O₆S₂
• Molecular Weight: 713.133
• Hs Code.: 2933399090
• European Community (EC) Number: 630-398-7
• NCI Thesaurus Code: C66256
• RXCUI: 236486
• Mol file: 95382-33-5.mol

Synonyms:H 168 68;H 168-68;H 16868;Magnesium, Omeprazole;Omeprazole;Omeprazole Magnesium;Omeprazole Sodium;Prilosec;Sodium, Omeprazole

Chemical Property of Prilosec OTC

Chemical Property:

• Boiling Point: 600 °C at 760 mmHg
• Flash Point: 316.7 °C
• PSA: 96.31000
• LogP: 3.99040
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Very slightly soluble in water, sparingly soluble in methanol, practically insoluble in heptane.
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 5
• Exact Mass: 369.0997543
• Heavy Atom Count: 25
• Complexity: 453

Purity/Quality:

97% ^*data from raw suppliers

Omeprazole magnesium ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC.[Mg]
• Recent ClinicalTrials: A Pharmacodynamic Study Comparing Zegerid? and Prilosec OTC? (CL2007-17 )(P07813)(COMPLETED)
• Recent EU Clinical Trials: A single centre, randomised, partially-blind, placebo-controlled 3 way crossover pilot study investigating efficacy in terms of heartburn relief after taking (2x250mg) Gaviscon? chewable tablets, (1x20mg) Losec? MUPS? tablet and (2x) Placebo tablets in subjects with heartburn following a refluxogenic meal.
• Uses: Omeprazole can inhibit the secretion of gastric acid, clinically used for treatment of heartburn and acid reflux caused by too much gastric acid. In addition, omeprazole magnesium enteric-coated tablets is used for the treatment of duodenal ulcer, gastric ulcer and reflux esophagitis: combined with antibiotics for the treatment of duodenal ulcer with helicobacter pylori infection ; treatment of non-steroidal anti-inflammatory drug-related peptic ulcer and gastroduodenal erosion; used to prevent non-steroidal anti-inflammatory drug-induced peptic ulcer, gastroduodenal erosion or indigestion symptoms; also for the long-term treatment of? chronic relapsing peptic ulcer and reflux esophagitis; symptomatic treatment of heartburn and regurgitation caused by gastro-oesophageal reflux disease; symptomatic treatment of ulcer-like symptoms and acid-related dyspepsia; treatment of Zollinger-Ellison syndrome. Omeprazole Magnesium is an inhibitor of gastric secretion. Used as an anttiulcerative. Anti Ulceratives

Technology Process of Prilosec OTC

There total 5 articles about Prilosec OTC which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

esomeprazole piperidine salt (1306616-22-7) + magnesium chloride (7786-30-3) → esomeprazole magnesium (161973-11-1,95382-33-5,161973-10-0)

Guidance literature:

In methanol; acetone; at 20 ℃; for 2.5h;

Reference yield:

(S)-(-)-binol-S-omeprazole inclusion complex (272776-12-2) → esomeprazole magnesium (161973-11-1,95382-33-5,161973-10-0)

Guidance literature:

(S)-(-)-binol-S-omeprazole inclusion complex; With sodium hydroxide; In Isopropyl acetate; water; at 20 ℃; pH=12;

With magnesium chloride; In methanol; water; at 20 - 25 ℃; for 4h; Product distribution / selectivity;

Reference yield:

esomeprazole sodium salt → esomeprazole magnesium (161973-11-1,95382-33-5,161973-10-0)

Guidance literature:

esomeprazole sodium salt; In water; at 1 - 25 ℃; for 1h;

With magnesium sulfate heptahydrate; In water; at 1 - 7 ℃; for 2.5h; Product distribution / selectivity;

upstream raw materials:

(S)-(-)-binol-S-omeprazole inclusion complex

omeprazole

omeprazole sulfide

esomeprazole piperidine salt

Downstream raw materials:

(S)-(-)-binol-S-omeprazole inclusion complex

Refernces

• 1、 -. "PROCESS FOR THE PREPARATION OF ESOMEPRAZOLE". Page/Page column 12-13. . Retrieved 2010/07/09.