cis-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate

Base Information

• Chemical Name: cis-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate
• CAS No.: 85650-55-1
• Molecular Formula: C₄H₄O₄*C₁₇H₁₆ClNO
• Molecular Weight: 401.847
• Mol file: 85650-55-1.mol

Synonyms:

Chemical Property of cis-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate

Chemical Property:

• Vapor Pressure: 1.62E-13mmHg at 25°C
• Boiling Point: 563.1°Cat760mmHg
• Flash Point: 294.4°C
• Density: g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate

There total 68 articles about cis-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.86%

asenapine (65576-45-6,65621-78-5) + maleic acid (110-16-7,26099-09-2) → trans-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz<2,3:6,7>oxepino<4,5-c>pyrrolidine maleate (85650-56-2,85650-55-1)

Guidance literature:

In ethanol; tert-butyl methyl ether; at 0 - 20 ℃; for 2h; Solvent; Temperature; Time;

Reference yield: 52.3%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + trans-5-chloro-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole hydrochloride (1170701-78-6) + maleic acid (110-16-7,26099-09-2) → trans-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz<2,3:6,7>oxepino<4,5-c>pyrrolidine maleate (85650-56-2,85650-55-1)

Guidance literature:

trans-5-chloro-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole hydrochloride; With sodium hydroxide; In dichloromethane; water; pH=> 10;

formaldehyd; With formic acid; In water; toluene; at 60 ℃; for 2h;

maleic acid;

Reference yield:

asenapine phosphate + maleic acid (110-16-7,26099-09-2) → trans-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz<2,3:6,7>oxepino<4,5-c>pyrrolidine maleate (85650-56-2,85650-55-1)

Guidance literature:

asenapine phosphate; With sodium hydrogencarbonate; In toluene; at 25 ℃; for 0.5h; Industry scale;

maleic acid; In isopropyl alcohol; at 25 - 50 ℃; Industry scale;

upstream raw materials:

asenapine

maleic acid

2'-chloro-benzeneacetic acid

4-chloro-phenol

Downstream raw materials:

asenapine

asenapine

Refernces

• 1、 -. "A method for the preparation of asenapine". Paragraph 0025-0027. . Retrieved 2017/02/09.
• 2、 -. "COMPRESSED ORAL DOSAGE FORM FOR ASENAPINE MALEATE". Page/Page column 28. . Retrieved 2013/04/10.