Carbamic acid, ethylmethyl-, 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester, monohydrochloride

Base Information

• Chemical Name: Carbamic acid, ethylmethyl-, 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester, monohydrochloride
• CAS No.: 727418-36-2
• Molecular Formula: C14H22N2O2.ClH
• Molecular Weight: 286.802
• Mol file: 727418-36-2.mol

Synonyms:

Chemical Property of Carbamic acid, ethylmethyl-, 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester, monohydrochloride

Chemical Property:

Purity/Quality:

98% HPLC ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, ethylmethyl-, 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester, monohydrochloride

There total 2 articles about Carbamic acid, ethylmethyl-, 3-[(1S)-1-(dimethylamino)ethyl]phenyl ester, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(S)-3-(1-dimethylaminoethyl)phenol hydrochloride (894079-56-2) + N-ethyl-N-methylcarbamoyl chloride (42252-34-6) → rivastigmine hydrochloride (727418-36-2)

Guidance literature:

(S)-3-(1-dimethylaminoethyl)phenol hydrochloride; N-ethyl-N-methylcarbamoyl chloride; With dmap; triethylamine; In dichloromethane; at 20 ℃; for 12h;

With sodium carbonate; In water; pH=10.5;

With hydrogenchloride; In water; at 0 ℃; Product distribution / selectivity;

Reference yield: 84.0%

4-nitrophenyl ethyl(methyl)carbamate (90870-20-5) + (S)-3-(1-dimethylaminoethyl)phenol hydrochloride (894079-56-2) → rivastigmine hydrochloride (727418-36-2)

Guidance literature:

4-nitrophenyl ethyl(methyl)carbamate; (S)-3-(1-dimethylaminoethyl)phenol hydrochloride; With potassium carbonate; In dimethyl sulfoxide; at 100 ℃; for 40h;

With hydrogenchloride; In water; at 20 ℃; for 2h; Product distribution / selectivity;

Reference yield: 66.3%

rivastigmine hydrochloride (727418-36-2) → rivastigmin (123441-03-2,415973-05-6)

Guidance literature:

With sodium hydroxide; In water; for 0.5h;

upstream raw materials:

4-nitrophenyl ethyl(methyl)carbamate

(S)-3-(1-dimethylaminoethyl)phenol hydrochloride

N-ethyl-N-methylcarbamoyl chloride

Downstream raw materials:

rivastigmin

Refernces