Benzenemethanamine, 2-bromo-4-fluoro-

Base Information

• Chemical Name: Benzenemethanamine, 2-bromo-4-fluoro-
• CAS No.: 739354-98-4
• Molecular Formula: C₇H₇BrFN
• Molecular Weight: 204.042
• Hs Code.: 2921499090
• Mol file: 739354-98-4.mol

Synonyms:

Chemical Property of Benzenemethanamine, 2-bromo-4-fluoro-

Chemical Property:

• Boiling Point: 244.4±25.0 °C(Predicted)
• PKA: 8.46±0.10(Predicted)
• PSA: 26.02000
• Density: 1.571±0.06 g/cm3(Predicted)
• LogP: 2.74720

Purity/Quality:

98% ^*data from raw suppliers

(2-bromo-4-fluorophenyl)methanamine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanamine, 2-bromo-4-fluoro-

There total 1 articles about Benzenemethanamine, 2-bromo-4-fluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-4-fluorobenzaldehyde (59142-68-6) → 1-(2-bromo-4-fluorophenyl)methan-1-amine (739354-98-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol; water / 12 h / 20 °C / Inert atmosphere

2: zinc; hydrogenchloride / ethanol; water / 2 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; hydroxylamine hydrochloride; sodium hydrogencarbonate; zinc; In ethanol; water;

DOI:10.1021/acs.orglett.7b03776

Reference yield:

1-(2-bromo-4-fluorophenyl)methan-1-amine (739354-98-4) → N-(2-bromo-4-fluorobenzyl)-2-morpholinoacetamide

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 2 h / 0 °C

2: potassium carbonate / tetrahydrofuran / Reflux

With potassium carbonate; In tetrahydrofuran; dichloromethane;

Reference yield:

1-(2-bromo-4-fluorophenyl)methan-1-amine (739354-98-4) → N-(2-bromo-4-fluorobenzyl)-2-morpholinoethylamine hydrochloride

Guidance literature:

Multi-step reaction with 3 steps

1.1: dichloromethane / 2 h / 0 °C

2.1: potassium carbonate / tetrahydrofuran / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 °C

3.2: 24 h / 20 °C

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; dichloromethane;

upstream raw materials:

2-bromo-4-fluorobenzaldehyde

Refernces