BUTTPARK 145\18-49

Base Information

• Chemical Name: BUTTPARK 145\18-49
• CAS No.: 74695-40-2
• Molecular Formula: C7H5NO2S
• Molecular Weight: 167.18500
• Mol file: 74695-40-2.mol

Synonyms:7-hydroxy-4H-thieno[3,2-b]pyridin-5-one;

Chemical Property of BUTTPARK 145\18-49

Chemical Property:

• PSA: 81.59000
• LogP: 1.70750
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Thieno[3,2-b]pyridine-5,7-diol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BUTTPARK 145\18-49

There total 3 articles about BUTTPARK 145\18-49 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-amino-2-thiophenecarboxylate (31823-64-0) → 7-hydroxythieno<2,3-b>pyridin-5(4H)-one (74695-40-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / 1.5 h / Heating

2: 73 percent / NaOEt / ethanol / 8 h / Heating

3: 1) 20percent aq. NaOH, 2) conc. HCl / 1) heating, 2 h, 2) heating

With hydrogenchloride; sodium hydroxide; sodium ethanolate; In ethanol;

Reference yield:

ethyl N-(2-ethoxycarbonyl-3-thienyl)malonamate (74695-28-6) → 7-hydroxythieno<2,3-b>pyridin-5(4H)-one (74695-40-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / NaOEt / ethanol / 8 h / Heating

2: 1) 20percent aq. NaOH, 2) conc. HCl / 1) heating, 2 h, 2) heating

With hydrogenchloride; sodium hydroxide; sodium ethanolate; In ethanol;

Reference yield:

6-ethoxycarbonyl-7-hydroxythieno<3,2-b>pyridin-5(4H)-one (74695-36-6) → 7-hydroxythieno<2,3-b>pyridin-5(4H)-one (74695-40-2)

Guidance literature:

With hydrogenchloride; sodium hydroxide; Yield given. Multistep reaction; 1) heating, 2 h, 2) heating;

upstream raw materials:

6-ethoxycarbonyl-7-hydroxythieno<3,2-b>pyridin-5(4H)-one

methyl 3-amino-2-thiophenecarboxylate

ethyl N-(2-ethoxycarbonyl-3-thienyl)malonamate

Downstream raw materials:

7-chloro-5-methoxythieno<3,2-b>pyridine

7-chlorothieno<3,2-b>pyridin-5(4H)-one

5,7-dichlorothieno<3,2-b>pyridine

Refernces