Methyl 3-chloro-4-forMylbenzoate

Base Information

• Chemical Name: Methyl 3-chloro-4-forMylbenzoate
• CAS No.: 74733-26-9
• Molecular Formula: C9H7ClO3
• Molecular Weight: 198.606
• Hs Code.: 2918300090
• Mol file: 74733-26-9.mol

Synonyms:4-carbomethoxy-2-chlorobenzaldehyde;3-chloro-4-formylbenzoic acid methyl ester;

Chemical Property of Methyl 3-chloro-4-forMylbenzoate

Chemical Property:

• Boiling Point: 315.8±27.0 °C(Predicted)
• PSA: 43.37000
• Density: 1.315±0.06 g/cm3(Predicted)
• LogP: 1.93910
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99.90% ^*data from raw suppliers

Methyl3-chloro-4-formylbenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 3-chloro-4-forMylbenzoate

There total 6 articles about Methyl 3-chloro-4-forMylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + 4-bromo-2-chlorobenzaldehyde (158435-41-7) → methyl 3-chloro-4-formyl-benzoate (74733-26-9)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; at 60 ℃;

Reference yield: 63.0%

methyl 3-chloro-4-(dibromomethyl)benzoate (1134777-59-5) → methyl 3-chloro-4-formyl-benzoate (74733-26-9)

Guidance literature:

With silver nitrate; In water; acetone; at 20 ℃; for 3h;

DOI:10.1021/jm401695d

Reference yield: 63.0%

→ methyl 3-chloro-4-formyl-benzoate (74733-26-9)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 4h; Reflux;

With silver nitrate; In water; acetone; at 20 ℃; for 3h;

upstream raw materials:

methyl 3-chloro-4-(dibromomethyl)benzoate

methyl 4-Bromomethyl-3-chlorobenzoate

methyl 3-chloro-4-methyl-benzoate

methanol

Downstream raw materials:

methyl 3-chloro-4-(oxazol-5-yl)benzoate

2,5-dioxopyrrolidin-1-yl 4-{[2-chloro-4-(morpholine-4-carbonyl)phenyl]methyl}piperazine-1-carboxylate

4-[[3-chloro-4-(piperazin-1-ylmethyl)phenyl]carbonyl]morpholine

tert-butyl 4-([2-chloro-4-[(morpholin-4-yl)carbonyl]phenyl]methyl)piperazine-1-carboxylate

Refernces

• 1、 -. "PYRROLO-PYRROLE CARBAMATE AND RELATED ORGANIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND MEDICAL USES THEREOF". Paragraph 00657; 00658. . Retrieved 2015/01/16.
• 2、 -. "NMDA RECEPTOR MODULATORS AND USES RELATED THERETO". Page/Page column 27; 34; 37. . Retrieved 2014/03/21.