2-AMINO-5-CHLOROBENZYL ALCOHOL

Base Information

• Chemical Name: 2-AMINO-5-CHLOROBENZYL ALCOHOL
• CAS No.: 748805-85-8
• Molecular Formula: C7H8FNO
• Molecular Weight: 141.145
• Hs Code.: 2922199090
• Mol file: 748805-85-8.mol

Synonyms:4-Fluoro-2-hydroxymethylaniline;

Chemical Property of 2-AMINO-5-CHLOROBENZYL ALCOHOL

Chemical Property:

• Melting Point: 107-109 °C (lit.)
• Boiling Point: 286 °C at 760 mmHg
• Flash Point: 126.8 °C
• PSA: 46.25000
• Density: 1.286 g/cm³
• LogP: 1.48140
• Storage Temp.: Room temperature.

Purity/Quality:

98.5% ^*data from raw suppliers

4-Fluoro-2-hydroxymethylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-5-CHLOROBENZYL ALCOHOL

There total 4 articles about 2-AMINO-5-CHLOROBENZYL ALCOHOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-amino-5-fluorobenzoic acid (446-08-2) → (2-amino-5-fluorophenyl)methanol (748805-85-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/cs4000014

Reference yield: 87.0%

(5-Fluoro-2-nitrophenyl)-methanol (287121-32-8) → (2-amino-5-fluorophenyl)methanol (748805-85-8)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; for 2h; Reflux;

DOI:10.1002/anie.201705746

Reference yield: 81.0%

→ (2-amino-5-fluorophenyl)methanol (748805-85-8)

Guidance literature:

upstream raw materials:

2-amino-5-fluorobenzoic acid

(5-Fluoro-2-nitrophenyl)-methanol

5-fluoro-2-nitrobenzaldehyde

Downstream raw materials:

2,2'-selenobis(5-fluorobenzyl alcohol)

N-(4-fluoro-2-(hydroxymethyl)phenyl)-4-methylbenzenesulfonamide

N-(4-fluoro-2-formylphenyl)-4-methyl-N-(2-oxo-2-phenylethyl)benzenesulfonamide

(R)-6-fluoro-3-hydroxy-3-phenyl-1-tosyl-2,3-dihydroquinolin-4(1H)-one

Refernces

• 1、 Fairuz Binte Sheikh Ismail, Siti Nur,Yang, Binmiao,Zhao, Yu. "Access to 5,6-Spirocycles Bearing Three Contiguous Stereocenters via Pd-Catalyzed Stereoselective [4 + 2] Cycloaddition of Azadienes". supporting information. p. 2884 - 2889. Retrieved 2021/05/05.
• 2、 Zhang, Jingjing,Xu, Wentao,Qu, Yi,Liu, Yuxiu,Li, Yongqiang,Song, Hongjian,Wang, Qingmin. "Visible-light-induced radical isocyanide insertion protocol for the synthesis of difluoromethylated spiro[indole-3,3′-quinoline] derivatives". supporting information. p. 15212 - 15215. Retrieved 2020/12/21.