2-Bromo-6-chlorobenzyl bromide

Base Information

• Chemical Name: 2-Bromo-6-chlorobenzyl bromide
• CAS No.: 75002-98-1
• Molecular Formula: C7H5Br2Cl
• Molecular Weight: 284.378
• Hs Code.: 2903999090
• European Community (EC) Number: 673-939-2
• DSSTox Substance ID: DTXSID40373604
• Wikidata: Q82161834
• Mol file: 75002-98-1.mol

Synonyms:1-bromo-2-(bromomethyl)-3-chlorobenzene;75002-98-1;2-Bromo-6-chlorobenzyl bromide;2-Bromo-6-chlorobenzylbromide;MFCD04038394;1-bromo-2-(bromomethyl)-3-chloro-benzene;Benzene, 1-bromo-2-(bromomethyl)-3-chloro-;SCHEMBL695878;6-chloro-alpha,2-dibromotoluene;2-Chloro-alpha,6-dibromotoluene;DTXSID40373604;AHZWBOMWAKYLIS-UHFFFAOYSA-N;AKOS000478988;AB91638;AM62186;CS-W006355;DS-14296;FT-0691576;EN300-267585;A865753;1-Bromo-2-(bromomethyl)-3-chlorobenzene, AldrichCPR

Chemical Property of 2-Bromo-6-chlorobenzyl bromide

Chemical Property:

• Melting Point: 62-64°C
• Boiling Point: 283.4±25.0 °C(Predicted)
• PSA: 0.00000
• Density: 1.93g/ml
• LogP: 3.99740
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 1
• Exact Mass: 283.84260
• Heavy Atom Count: 10
• Complexity: 108

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-6-chlorobenzyl bromide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C(=C1)Br)CBr)Cl

Technology Process of 2-Bromo-6-chlorobenzyl bromide

There total 1 articles about 2-Bromo-6-chlorobenzyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-bromo-6-chlorotoluene (62356-27-8) → 1-bromo-2-(bromomethyl)-3-chlorobenzene (75002-98-1)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In chloroform; at 60 ℃; for 8h; Inert atmosphere;

DOI:10.1039/c2ob26110c

Reference yield: 90.0%

1-bromo-2-(bromomethyl)-3-chlorobenzene (75002-98-1) + cyanoacetic acid amide (107-91-5) → 3-(2-bromo-6-chlorobenzyl)-5-chloro-2-oxo-1,2,3,4-tetrahydroquinoline-3-carbonitrile

Guidance literature:

With copper(l) iodide; potassium carbonate; In ethylene glycol; at 110 ℃; for 2h;

DOI:10.1002/ejoc.201301373

Reference yield: 85.0%

salicylonitrile (611-20-1) + 1-bromo-2-(bromomethyl)-3-chlorobenzene (75002-98-1) → 2-((2-bromo-6-chlorobenzyl)oxy)benzonitrile

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 0.166667h;

DOI:10.1039/d0cc01172j

upstream raw materials:

2-bromo-6-chlorotoluene

Downstream raw materials:

2-(2-bromo-6-chlorophenyl)acetonitrile

6-(2-bromo-6-chlorophenyl)pyrido[2,3-d]pyrimidin-7-amine

6-(2-bromo-6-chlorophenyl)-2-methylpyrido[2,3-d]-pyrimidin-7-amine

4'-chloro-2',3'-dihydrospiro[cyclohexa[2,5]diene-1,1'-inden]-4-one

Refernces

• 1、 -. "A two-benzo heterocyclic compound and its preparation method and application (by machine translation)". Paragraph 0065-0072. . Retrieved 2019/05/08.
• 2、 -. "DIFLUOROMETHYLENE COMPOUND". Paragraph 0404; 0405. . Retrieved 2015/06/16.