(2R)-2-Fluoropropanoic acid

Base Information

• Chemical Name: (2R)-2-Fluoropropanoic acid
• CAS No.: 75244-22-3
• Molecular Formula: C3H5FO2
• Molecular Weight: 92.0699
• DSSTox Substance ID: DTXSID70451126
• Nikkaji Number: J945.050E
• Wikidata: Q82271000
• Mol file: 75244-22-3.mol

Synonyms:(2R)-2-Fluoropropanoic acid;75244-22-3;CTK2G1121;(r)-2-fluoropropionic acid;(R)-2-Fluoropropanoic acid;DTXSID70451126;CS-0435455;EN300-4271512

Chemical Property of (2R)-2-Fluoropropanoic acid

Chemical Property:

• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 92.02735756
• Heavy Atom Count: 6
• Complexity: 61.8

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(=O)O)F
• Isomeric SMILES: C[C@H](C(=O)O)F

Technology Process of (2R)-2-Fluoropropanoic acid

There total 15 articles about (2R)-2-Fluoropropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

ethyl 2-fluoropropionate (349-43-9,127306-59-6) → 2-fluoropropanoic acid (57965-29-4,75244-22-3,105229-18-3,6087-13-4)

Guidance literature:

With sodium hydroxide; In ethanol; water; for 1h; Reflux;

DOI:10.1021/acsmedchemlett.6b00467

Reference yield: 90.0%

methyl 2-fluoropropanoate (2366-56-5) → 2-fluoropropanoic acid (57965-29-4,75244-22-3,105229-18-3,6087-13-4)

Guidance literature:

With formic acid;

DOI:10.1016/S0040-4039(00)60570-1

Reference yield: 90.0%

2-Fluoro-propionic acid isopropyl ester (114435-93-7) → 2-fluoropropanoic acid (57965-29-4,75244-22-3,105229-18-3,6087-13-4)

Guidance literature:

With formic acid;

DOI:10.1016/S0040-4039(00)60570-1

upstream raw materials:

2-Fluoropropanamide

2-fluoro-propionitrile

diethyl 2-methyl-2-fluoromalonate

rac-Ala-OH

Downstream raw materials:

methyl (R)-2-benzyl-2-fluoro-3-((R)-2-fluoropropanamido)propanoate

C₁₇H₁₇FN₂O₃

C₁₇H₁₇FN₂O₃

C₁₇H₁₇FN₂O₃

Refernces

• 1、 Keller, Max,Maschauer, Simone,Brennauer, Albert,Tripal, Philipp,Koglin, Norman,Dittrich, Ralf,Bernhardt, Günther,Kuwert, Torsten,Wester, Hans-Jürgen,Buschauer, Armin,Prante, Olaf. "Prototypic 18F-Labeled Argininamide-Type Neuropeptide Y Y1R Antagonists as Tracers for PET Imaging of Mammary Carcinoma". supporting information. p. 304 - 309. Retrieved 2017/03/17.
• 2、 Hao, Lan-Hu,Li, Yan-Ping,He, Wei-Ying,Wang, Hui-Qiang,Shan, Guang-Zhi,Jiang, Jian-Dong,Li, Yu-Huan,Li, Zhuo-Rong. "Synthesis and antiviral activity of substituted bisaryl amide compounds as novel influenza virus inhibitors". . p. 117 - 124. Retrieved 2012/11/07.