Imidazo[1,2-a]pyrimidine-2-carboxylic acid, 5,7-dimethyl-, ethyl ester

Base Information

• Chemical Name: Imidazo[1,2-a]pyrimidine-2-carboxylic acid, 5,7-dimethyl-, ethyl ester
• CAS No.: 76075-25-7
• Molecular Formula: C₁₁H₁₃N₃O₂
• Molecular Weight: 219.243
• Hs Code.: 2933599590
• Mol file: 76075-25-7.mol

Synonyms:5,7-Dimethyl-imidazo[1,2-a]pyrimidine-2-carboxylic acid ethyl ester;

Chemical Property of Imidazo[1,2-a]pyrimidine-2-carboxylic acid, 5,7-dimethyl-, ethyl ester

Chemical Property:

• Melting Point: 195 - 197 °C (benzene)
• PSA: 56.49000
• LogP: 1.52280

Purity/Quality:

99%min. ^*data from raw suppliers

Ethyl5,7-dimethylimidazo[1,2-a]pyrimidine-2-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Imidazo[1,2-a]pyrimidine-2-carboxylic acid, 5,7-dimethyl-, ethyl ester

There total 2 articles about Imidazo[1,2-a]pyrimidine-2-carboxylic acid, 5,7-dimethyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

2-Amino-4,6-dimethylpyrimidine (767-15-7,184433-59-8) + ethyl Bromopyruvate (70-23-5) → ethyl 5,7-dimethylimidazo<1,2-a>pyrimidine-2-carboxylate (76075-25-7)

Guidance literature:

In ethanol; for 3h; Heating;

Reference yield:

2-oxo-propionic acid ethyl ester (617-35-6) → ethyl 5,7-dimethylimidazo<1,2-a>pyrimidine-2-carboxylate (76075-25-7)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine / dioxane; diethyl ether / 1 h

2: 1,2-dimethoxy-ethane / 48 h / Heating

With bromine; In 1,4-dioxane; 1,2-dimethoxyethane; diethyl ether;

DOI:10.1248/cpb.40.1170

upstream raw materials:

2-Amino-4,6-dimethylpyrimidine

ethyl Bromopyruvate

2-oxo-propionic acid ethyl ester

Refernces

• 1、 Abignente,Arena,de Caprariis,Montagnaro,Rossi,Lampa,Giordano,Vacca,Marmo. "Research on heterocyclic compounds. IX - Heteroarylcarboxamides and acetamides: Antiinflammatory and related pharmacological properties". . p. 654 - 673. Retrieved 2007/10/02.