2-Phenoxybiphenyl

Base Information

• Chemical Name: 2-Phenoxybiphenyl
• CAS No.: 6738-04-1
• Molecular Formula: C18H14 O
• Molecular Weight: 246.309
• Hs Code.: 2909309090
• European Community (EC) Number: 229-793-3,249-357-6
• NSC Number: 66280
• UNII: 051GW48I3F
• DSSTox Substance ID: DTXSID10891183
• Nikkaji Number: J110.671F
• Wikidata: Q27236056
• Mol file: 6738-04-1.mol

Synonyms:2-Phenoxybiphenyl;6738-04-1;2-Biphenylyl phenyl ether;Ether, 2-biphenylyl phenyl;o-Diphenyl phenyl ether;1,1'-Biphenyl, 2-phenoxy-;1-phenoxy-2-phenylbenzene;2-Phenyloxybiphenyl;Phenoxy-2-diphenyl;1,1'-Biphenyl, phenoxy-;2-Phenoxy-1,1'-biphenyl;Phenyl biphenyl ether;Ether, biphenylyl phenyl;Phenoxy-1,1'-biphenyl;BIPHENYLYL PHENYL ETHER;051GW48I3F;EINECS 249-357-6;NSC 66280;NSC-66280;28984-89-6;o-phenoxybiphenyl;2-Phenoxydiphenyl;1, 2-phenoxy-;2-Biphenyl phenyl ether;(2-PHENYLOXY)BIPHENYL;UNII-051GW48I3F;SCHEMBL1958156;2-BiphenylylphenylA currencyther;DTXSID10891183;NSC66280;EINECS 229-793-3;GEO-02598;MFCD00003035;LS-44522;AI3-02477;W-200057;Q27236056

Chemical Property of 2-Phenoxybiphenyl

Chemical Property:

• Melting Point: 48-50°C
• Boiling Point: 200-201 °C
• PSA: 9.23000
• Density: 1.093
• LogP: 5.14590
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 246.104465066
• Heavy Atom Count: 19
• Complexity: 250

Purity/Quality:

99% ^*data from raw suppliers

2-BIPHENYLYL PHENYL ETHER AldrichCPR ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC=CC=C2OC3=CC=CC=C3

Technology Process of 2-Phenoxybiphenyl

There total 29 articles about 2-Phenoxybiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

bis(2,2'-bisphenylylene)selenurane (19615-37-3) + phenol (108-95-2,27073-41-2) → dibenzo[b,d]selenophene (244-95-1) + 2-phenoxy-1,1'-biphenyl (6738-04-1)

Guidance literature:

In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1246/cl.1994.889

Reference yield: 97.0%

bis(2,2'-biphenylylene)sulfurane (144190-64-7) + phenol (108-95-2,27073-41-2) → dibenzothiophene (132-65-0) + 2-phenoxy-1,1'-biphenyl (6738-04-1)

Guidance literature:

In tetrahydrofuran; at -78 - 25 ℃;

Reference yield: 90.0%

bromobenzene (108-86-1,52753-63-6) + 2-Phenylphenol (90-43-7,287950-96-3) → 2-phenoxy-1,1'-biphenyl (6738-04-1)

Guidance literature:

With potassium phosphate; Cu(2,2'-bipyridyl)2BF₄; In N,N-dimethyl-formamide; at 110 ℃; for 24h;

DOI:10.1021/jo801002c

upstream raw materials:

2-iodobiphenyl

potassium phenolate

diphenylether

chlorobenzene

Downstream raw materials:

2,2''-oxydi-1,1'-biphenyl

biphenyl

(1,1';3',1''-terphenyl)-2'-ol

2-Phenylphenol

Refernces

• 1、 Liu, Le,Nevado, Cristina. "Diaryl Ether Formation Merging Photoredox and Nickel Catalysis". supporting information. p. 2188 - 2193. Retrieved 2021/05/04.
• 2、 Yadav, M. Ramu,Nagaoka, Masahiro,Kashihara, Myuto,Zhong, Rong-Lin,Miyazaki, Takanori,Sakaki, Shigeyoshi,Nakao, Yoshiaki. "The Suzuki-Miyaura Coupling of Nitroarenes". . p. 9423 - 9426. Retrieved 2017/07/24.