Ethyl 2-ethoxy-2-hydroxyacetate

Base Information

• Chemical Name: Ethyl 2-ethoxy-2-hydroxyacetate
• CAS No.: 49653-17-0
• Molecular Formula: C6H12O4
• Molecular Weight: 148.159
• European Community (EC) Number: 256-411-2
• NSC Number: 25308
• DSSTox Substance ID: DTXSID201303847
• Nikkaji Number: J236.715G
• Mol file: 49653-17-0.mol

Synonyms:ethyl 2-ethoxy-2-hydroxyacetate;49653-17-0;Ethyl ethoxyhydroxyacetate;Ethyl glyoxylate hemiacetal;EINECS 256-411-2;NSC 25308;SCHEMBL17504;Ethyl ethoxy(hydroxy)acetate #;ethyl (hydroxy)(ethoxy)-acetate;2-Ethoxyglycolic acid ethyl ester;DTXSID201303847;NSC25308;NSC-25308;AKOS006283055;Acetic acid, ethoxyhydroxy-, ethyl ester;FT-0639875;A20366

Chemical Property of Ethyl 2-ethoxy-2-hydroxyacetate

Chemical Property:

• Vapor Pressure: 0.365mmHg at 25°C
• Melting Point: 134.5-136.0 °C
• Boiling Point: 174.9°Cat760mmHg
• PKA: 11.24±0.20(Predicted)
• Flash Point: 61.1°C
• PSA: 55.76000
• Density: 1.095g/cm³
• LogP: -0.09560
• Solubility.: Chloroform, Ethanol, Methanol
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 148.07355886
• Heavy Atom Count: 10
• Complexity: 102

Purity/Quality:

99% ^*data from raw suppliers

ETHYL 2-ETHOXY-2-HYDROXYACETATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(C(=O)OCC)O
• Uses: Ethyl 2-Ethoxy-2-hydroxyacetate_x000D__x000D_DISCONTINUED (cas# 49653-17-0) is a compound useful in organic synthesis.

Technology Process of Ethyl 2-ethoxy-2-hydroxyacetate

There total 18 articles about Ethyl 2-ethoxy-2-hydroxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

ethanol (64-17-5) + Glyoxilic acid (298-12-4) → ethyl 2-ethoxyglycolate (49653-17-0)

Guidance literature:

at 80 ℃; for 114h;

DOI:10.1055/s-1994-25656

Reference yield:

Terephthalic acid bis-(ethoxy-ethoxycarbonyl-methyl) ester → ethyl 2-ethoxyglycolate (49653-17-0) + terephthalic acid (100-21-0)

Guidance literature:

With pancrease lipase; In hexane; water; at 30 ℃; for 2h;

Reference yield:

ethyl 2-bromo-2-ethoxy-acetate (57941-45-4) → ethyl 2-ethoxyglycolate (49653-17-0)

Guidance literature:

With sodium hydroxide;

upstream raw materials:

dichloro-acetic acid

sodium ethanolate

glyoxylic acid ethyl ester

ethanol

Downstream raw materials:

ethyl (E)-3-formyl-2-butenoate

2-benzoylbut-2-enedioic acid diethyl ester

4-oxo-but-2-enoic acid ethyl ester

(Z)-4-oxo-2-butenoic acid ethyl ester

Refernces

• 1、 -. "CROSSLINKING AGENT, CROSSLINKED POLYMER, AND USES THEREOF". Page/Page column 20. . Retrieved 2010/08/22.
• 2、 Klemm, D.,Geschwend, G.. "ENZYLATICALLY CLEAVABLE ALKOXYCARBONYL ETHOXYMETHYL ESTERS FOR REVERSIBLE BLOCKING OF CARBOXYL GROUPS". . p. 2337 - 2348. Retrieved 2007/10/02.