1-(2,4,5-trihydroxyphenyl)ethanone

Base Information

• Chemical Name: 1-(2,4,5-trihydroxyphenyl)ethanone
• CAS No.: 1818-27-5
• Molecular Formula: C8H8O4
• Molecular Weight: 168.149
• Hs Code.: 2914501900
• Mol file: 1818-27-5.mol

Synonyms:1-acetyl-2,4,5-trihydroxybenzene;Acetophenone,2,4,5-trihydroxy;Ethanone, 1-(2,4,5-trihydroxyphenyl)-;2,4,5-trihydroxyacetophenone;

Chemical Property of 1-(2,4,5-trihydroxyphenyl)ethanone

Chemical Property:

• Vapor Pressure: 4.1E-07mmHg at 25°C
• Melting Point: 200-202 °C
• Boiling Point: 404.3°Cat760mmHg
• PKA: 7.81±0.23(Predicted)
• Flash Point: 212.4°C
• PSA: 77.76000
• Density: 1.446g/cm³
• LogP: 1.00600
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(2,4,5-Trihydroxy-phenyl)-ethanone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2,4,5-trihydroxyphenyl)ethanone

There total 14 articles about 1-(2,4,5-trihydroxyphenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.6%

2',4',5'-trimethoxyacetophenone (1818-28-6) → 1-(2,4,5-trihydroxyphenyl)ethanone (1818-27-5)

Guidance literature:

With boron tribromide; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield: 66.9%

1-<4,5-(methylenedioxy)-2-hydroxyphenyl>ethanone (66003-50-7) → 1-(2,4,5-trihydroxyphenyl)ethanone (1818-27-5)

Guidance literature:

With trichlorosilane; In chlorobenzene; at 20 ℃; for 24h; Inert atmosphere;

Reference yield: 30.6%

acetic anhydride (108-24-7) + p-benzoquinone (106-51-4) → 1-(2,4,5-trihydroxyphenyl)ethanone (1818-27-5)

Guidance literature:

acetic anhydride; p-benzoquinone; With sulfuric acid; at 50 ℃; for 0.25h; Neat (no solvent);

With water; at 135 ℃;

With toluene-4-sulfonic acid; for 1h; Reflux;

DOI:10.1016/j.bmc.2009.07.072

upstream raw materials:

2',4'-dihydroxy-4-acetophenone

1,2,4-triacetoxybenzene

1,2,4-Trihydroxybenzene

acetic anhydride

Downstream raw materials:

3,4,2',4',5'-pentahydroxy-trans-chalcone

1-<4,5-(methylenedioxy)-2-hydroxyphenyl>ethanone

2',4',5'-tribenzyloxyacetophenone

2-hydroxy-4,5-dimethoxyacetophenone

Refernces

• 1、 -. "Compound for treating or preventing hepatopathy (by machine translation)". Paragraph 0253-0254; 0257. . Retrieved 2019/10/01.
• 2、 -. "A 2, 4, 5 - trihydroxy - 3 - bromophenylmethyl synthetic method (by machine translation)". Paragraph 0023; 0024. . Retrieved 2018/06/15.