2-Methylbenzohydrazide

Base Information

• Chemical Name: 2-Methylbenzohydrazide
• CAS No.: 7658-80-2
• Molecular Formula: C8H10N2O
• Molecular Weight: 150.18
• Hs Code.: 29280090
• European Community (EC) Number: 231-623-8
• NSC Number: 61566
• UNII: 6CDR3O391Q
• DSSTox Substance ID: DTXSID30227384
• Nikkaji Number: J307.913I
• Wikidata: Q72509276
• Mol file: 7658-80-2.mol

Synonyms:2-Methylbenzohydrazide;7658-80-2;o-Toluic hydrazide;o-Toluic acid hydrazide;o-Toluohydrazide;2-Methyl-benzoic acid hydrazide;2-Toluic hydrazide;Benzoic acid, 2-methyl-, hydrazide;2-Methylbenzoic acid hydrazide;6CDR3O391Q;EINECS 231-623-8;NSC 61566;NSC-61566;AI3-32878;methylbenzohydrazide;2-Methylbenzhydrazide;O-TOLUOYLHYDRAZINE;2-Methylbenzohydrazide #;2-TOLUOYLHYDRAZINE;UNII-6CDR3O391Q;SCHEMBL1128274;O-METHYLBENZOYL HYDRAZIDE;O-TOLUIC ACID, HYDRAZIDE;2-METHYLBENZOIC HYDRAZIDE;(O-METHYLBENZOYL)HYDRAZINE;DTXSID30227384;2-METHYLBENZOCARBOHYDRAZIDE;(2-METHYLBENZOYL)HYDRAZINE;NSC61566;BBL008111;MFCD00014756;STK009886;O-METHYLBENZOIC ACID HYDRAZIDE;AKOS000194934;GS-3017;SB85979;2-Methylbenzohydrazide, o-Toluic hydrazide;BB 0240952;CS-0096270;FT-0636547;EN300-16650;2-METHYLBENZENECARBOXYLIC ACID HYDRAZIDE;H11322;A838754;Z56347320

Chemical Property of 2-Methylbenzohydrazide

Chemical Property:

• Appearance/Colour: off-white to light beige powder
• Melting Point: 121-125 °C
• Refractive Index: 1.568
• PSA: 55.12000
• Density: 1.127 g/cm³
• LogP: 1.68970
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 150.079312947
• Heavy Atom Count: 11
• Complexity: 147

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Toluic hydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CC=C1C(=O)NN

Technology Process of 2-Methylbenzohydrazide

There total 9 articles about 2-Methylbenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-Methyl-benzoic acid methyl ester (89-71-4) → 2-methylbenzohydrazide (7658-80-2)

Guidance literature:

With hydrazine hydrate; In ethanol;

DOI:10.1016/j.bmc.2005.05.011

Reference yield: 90.0%

ethyl 2-methylbenzoate (87-24-1) → 2-methylbenzohydrazide (7658-80-2)

Guidance literature:

With hydrazine hydrate; In ethanol; water; Reflux;

DOI:10.1016/j.bmc.2015.06.051

Reference yield: 90.0%

ortho-methylbenzoic acid (118-90-1) → 2-methylbenzohydrazide (7658-80-2)

Guidance literature:

ortho-methylbenzoic acid; With sulfuric acid; In ethanol; for 6h; Reflux;

With hydrazine hydrate; sodium hydrogencarbonate; acetic acid; Reflux;

DOI:10.1016/j.ejmech.2017.06.036

upstream raw materials:

2-Methyl-benzoic acid methyl ester

ethyl 2-methylbenzoate

ortho-toluoyl chloride

ortho-methylbenzoic acid

Downstream raw materials:

N-(N-benzyloxycarbonyl-L-alanyl)-N'-o-toluoyl-hydrazine

N-(N-benzoyl-L-alanyl)-N'-o-toluoyl-hydrazine

N,N'-di-o-toluoyl-hydrazine

azido(2-tolyl)methanone

Refernces

• 1、 Joly, Nicolas,Bettoni, Léo,Gaillard, Sylvain,Poater, Albert,Renaud, Jean-Luc. "Phosphine-free ruthenium complex-catalyzed synthesis of mono- Or dialkylated acyl hydrazides via the borrowing hydrogen strategy". . p. 6813 - 6825. Retrieved 2021/05/29.
• 2、 Cheng, Wanqing,Fan, Jiangping,Guo, Yong,Han, Meiyue,Ma, Nannan,Yan, Xiaoting,Yang, Ruige. "Development of Novel (+)-Nootkatone Thioethers Containing 1,3,4-Oxadiazole/Thiadiazole Moieties as Insecticide Candidates against Three Species of Insect Pests". . p. 15544 - 15553. Retrieved 2022/01/03.