Ferriheme hydroxide

Base Information

• Chemical Name: Ferriheme hydroxide
• CAS No.: 15489-90-4
• Molecular Formula: C34H31 Fe N4 O5 . 2 H
• Molecular Weight: 633.507
• Hs Code.: 2934999090
• European Community (EC) Number: 239-518-9
• Mol file: 15489-90-4.mol

Synonyms:Alkaline Hematin D 575;Alkaline Hematin D-575;Chloride, Ferriheme;Chloride, Ferriprotoporphyrin IX;Chlorohemin;Ferrihaem;Ferriheme Chloride;Ferriprotoporphyrin;Ferriprotoporphyrin IX;Ferriprotoporphyrin IX Chloride;Hematin;Hematin D-575, Alkaline;Hemin;Panhematin;Protohemin;Protohemin IX

Chemical Property of Ferriheme hydroxide

Chemical Property:

• Appearance/Colour: Dark crystals with metalic luster
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 180 °C
• Boiling Point: 1128.5 °C at 760 mmHg
• Flash Point: 636.3 °C
• PSA: 129.41000
• Density: g/cm³
• LogP: 3.43290
• Storage Temp.: 2-8°C
• Solubility.: DMF (Slightly), DMSO (Slightly, Heated, Sonicated), Pyridine (Slightly, Heated,
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 8
• Exact Mass: 634.187856
• Heavy Atom Count: 44
• Complexity: 1580

Purity/Quality:

98%,99%, ^*data from raw suppliers

Hematein for microscopy (Hist.) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)C=C)C)C=C)C(=C3CCC(=O)O)C)CCC(=O)O.O.[Fe+2]
• Description: Produced from red blood cells, Hematin is a bluish-black or brownish pigment compound derived from hemoglobin by removal of the protein part and oxidation of the iron atom from ferrous Fe2+ to the ferric Fe3+ state, which does not combine with oxygen. It is effective to inhibit the synthesis of porphyrin and, at the same time, stimulate the synthesis of globin. It involves in the formation of cytochromes and peroxidases in the cell. Hematin is also a pharmaceutical used in the treatment of porphyria, which can be administered intravenously to halt the attack of acute porphyria. It functions in the liver to accelerate the production of heme and thus preventing the further accumulation of heme precursors, porphyrins, which is effective to alleviate the symptoms of porphyria.
• Uses: Indicator, biological stain. Hematin was used in a study to test in vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. It was also used in a study to test in-vitro bacterial identification using fluorescence spectroscopy with an optical fiber system.

Technology Process of Ferriheme hydroxide

There total 5 articles about Ferriheme hydroxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C54H55FeN6O6 → ferriprotoporphyrin IX hydroxide (15489-90-4) + quinidine (56-54-2)

Guidance literature:

In acetonitrile; Equilibrium constant;

DOI:10.1039/c5dt02671g

Reference yield:

C54H55FeN6O6 → ferriprotoporphyrin IX hydroxide (15489-90-4) + Quinine (130-95-0)

Guidance literature:

In acetonitrile; Equilibrium constant;

DOI:10.1039/c5dt02671g

Reference yield:

iron(III) protoporphyrin IX chloride (13496-05-4,16009-13-5) → ferriprotoporphyrin IX hydroxide (15489-90-4)

Guidance literature:

With sodium hydroxide; at 20 ℃; for 1h;

DOI:10.1039/c2ob25812a

upstream raw materials:

iron(III) protoporphyrin IX chloride

Fe(protoporphyrin-IX)(pyridine)2⁽¹⁺⁾

Refernces

• 1、 Lanfranchi, Don Antoine,Cesar-Rodo, Elena,Bertrand, Beno?t,Huang, Hsin-Hung,Day, Latasha,Johann, Laure,Elhabiri, Mourad,Becker, Katja,Williams, David L.,Davioud-Charvet, Elisabeth. "Synthesis and biological evaluation of 1,4-naphthoquinones and quinoline-5,8-diones as antimalarial and schistosomicidal agents". experimental part. p. 6375 - 6387. Retrieved 2012/09/05.