3,4-Dihydro-8-hydroxynaphthalen-1(2H)-one

Base Information

• Chemical Name: 3,4-Dihydro-8-hydroxynaphthalen-1(2H)-one
• CAS No.: 7695-47-8
• Molecular Formula: C10H10O2
• Molecular Weight: 162.188
• Hs Code.: 2914400090
• Mol file: 7695-47-8.mol

Synonyms:8-Hydroxy-3,4-dihydro-2H-naphthalin-1-on;8-hydroxy-3,4-dihydronaphthalen-1(2h)-one;hydroxy-8 tetralone-1;8-hydroxy-1,2,3,4-tetrahydro-1-naphthalenone;1-Tetralone,8-hydroxy;3,4-DIHYDRO-8-HYDROXYNAPHTHALEN-1(2H)-ONE;8-hydroxy-1-tetralone;

Chemical Property of 3,4-Dihydro-8-hydroxynaphthalen-1(2H)-one

Chemical Property:

• Vapor Pressure: 0.000104mmHg at 25°C
• Boiling Point: 327.7oC at 760 mmHg
• PKA: 8.35±0.20(Predicted)
• Flash Point: 139.2oC
• PSA: 37.30000
• Density: 1.236g/cm3
• LogP: 1.91120
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

8-hydroxy-3,4-dihydronaphthalen-1(2H)-one 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-Dihydro-8-hydroxynaphthalen-1(2H)-one

There total 2 articles about 3,4-Dihydro-8-hydroxynaphthalen-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tetralin (119-64-2) → 1-(1-allyl-2-phenyl-4-pentenyl)benzene + 1-methyl-1,2,3,4-tetrahydronaphthalene (1559-81-5) + 1,2,3,4-Tetrahydro-1-naphthol (529-33-9) + 8-hydroxy-1,2,3,4-tetrahydro-1-naphthalenone (7695-47-8) + 3,4-dihydronaphthalene-1(2H)-one (529-34-0)

Guidance literature:

With [Mn₂(2,5-dihydroxyterephthalate)(H₂O)₂]·nH₂O; oxygen; at 135 ℃; for 9h; Catalytic behavior;

DOI:10.1039/c7dt01351e

Reference yield:

benzyl 8-(benzyloxy)-1,2,3,4-tetrahydro-4-hydroxy-1-oxonaphthalene-2-carboxylate → isosclerone (51114-98-8,54712-38-8,62332-73-4,137494-04-3) + 8-hydroxy-1,2,3,4-tetrahydro-1-naphthalenone (7695-47-8)

Guidance literature:

benzyl 8-(benzyloxy)-1,2,3,4-tetrahydro-4-hydroxy-1-oxonaphthalene-2-carboxylate; With hydrogen; palladium on activated charcoal; In ethyl acetate; under 760 Torr;

In water; ethyl acetate; at 50 ℃; for 5h;

DOI:10.1002/hlca.200390014

Reference yield: 93.0%

8-hydroxy-1,2,3,4-tetrahydro-1-naphthalenone (7695-47-8) + benzyl chloride (100-44-7) → 8-benzyloxy-1,2,3,4-tetrahydro-1-naphthalenone (88058-45-1)

Guidance literature:

With potassium phosphate; In dimethyl sulfoxide; at 60 ℃; for 0.333333h;

DOI:10.1002/jhet.5570330104

upstream raw materials:

tetralin

Downstream raw materials:

8-methoxy-1-tetralone

8-benzyloxy-1,2,3,4-tetrahydro-1-naphthalenone

8-(4-chlorobenzyloxy)-1,2,3,4-tetrahydro-1-naphthalenone

4,5-dihydro-3H-naphtho<1,8-bc>furan

Refernces

• 1、 Couche, Emmanuel,Fkyerat, Abdellatif,Tabacchi, Raffaele. "Asymmetric synthesis of the cis- and trans-3,4-dihydro-2,4,8-trihydroxynaphthalen-1(2H)-ones". . p. 210 - 221. Retrieved 2007/10/03.