methyl 5-oxopentanoate

Base Information

• Chemical Name: methyl 5-oxopentanoate
• CAS No.: 6026-86-4
• Molecular Formula: C6H10O3
• Molecular Weight: 130.144
• Hs Code.: 2918300090
• Mol file: 6026-86-4.mol

Synonyms:Glutaraldehydicacid, methyl ester (6CI,7CI,8CI);5-Oxopentanoic acid methyl ester;Methyl4-formylbutanoate;Methyl 4-formylbutyrate;Methyl 5-oxopentanoate;Methyl5-oxovalerate;Methyl glutaraldehydate;Methyl g-formylbutyrate;g-Formylbutyric acid methyl ester;

Chemical Property of methyl 5-oxopentanoate

Chemical Property:

• Vapor Pressure: 0.579mmHg at 25°C
• Melting Point: 200-201 °C (decomp)
• Refractive Index: 1.41
• Boiling Point: 189.1 °C at 760 mmHg
• Flash Point: 72.1 °C
• PSA: 43.37000
• Density: 1.013 g/cm³
• LogP: 0.52860

Purity/Quality:

99%, ^*data from raw suppliers

METHYL-5-OXOPENTANOATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 5-oxopentanoate

There total 35 articles about methyl 5-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 5-hydroxypentanoate (14273-92-8) → methyl 4-formylbutanoate (6026-86-4)

Guidance literature:

methyl 5-hydroxypentanoate; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.5h;

With triethylamine; In dichloromethane;

DOI:10.1021/jacs.1c00886

Reference yield: 95.0%

methyl 4-(chlorocarbonyl)butyrate (1501-26-4) → methyl 4-formylbutanoate (6026-86-4)

Guidance literature:

With 2,6-dimethylpyridine; hydrogen; palladium on activated charcoal;

DOI:10.1016/S0040-4020(01)96002-8

Reference yield: 95.0%

methanol (67-56-1) + cyclopentene (142-29-0) → methyl 4-formylbutanoate (6026-86-4)

Guidance literature:

methanol; cyclopentene; With sodium hydrogencarbonate; ozone; In dichloromethane; at -78 ℃;

With acetic anhydride; triethylamine; In dichloromethane; at 0 ℃; for 4.25h; Inert atmosphere;

DOI:10.1002/anie.201106587

upstream raw materials:

methanol

2,2-dimethoxy-3,4-dihydropyrane

methyl 4-(chlorocarbonyl)butyrate

crotonic acid methyl ester

Downstream raw materials:

methyl 5,5-dimethoxyvalerate

methyl 5-hydroxypentanoate

5,5-bis-phenylsulfanyl-pentanoic acid

5,5-bis-phenylsulfanyl-pentanoyl chloride

Refernces

• 1、 Goese,Eisenreich,Kupfer,Stohler,Weber,Leuenberger,Bacher. "Biosynthesis of lipstatin. Incorporation of multiply deuterium-labeled (5Z,8Z)-tetradeca-5,8-dienoic acid and octanoic acid". . p. 4673 - 4678. Retrieved 2001.
• 2、 Nagib, David A.,Rafferty, Sean M.,Rutherford, Joy E.,Wang, Lu,Zhang, Lumin. "Cross-Selective Aza-Pinacol Coupling via Atom Transfer Catalysis". supporting information. p. 5622 - 5628. Retrieved 2021/05/07.
• 3、 -. "Bisheterocycle substituted oxa-spiro derivative, and preparation method and medical application thereof". Paragraph 0406-0408. . Retrieved 2020/09/23.