Levothyroxine sodium monohydrate

Base Information

• Chemical Name: Levothyroxine sodium monohydrate
• CAS No.: 25416-65-3
• Deprecated CAS: 61333-06-0
• Molecular Formula: C15H10I4NNaO4.xH2O
• Molecular Weight: 798.85200
• Hs Code.: 29379000
• European Community (EC) Number: 200-221-4,685-634-1
• UNII: B82379R9W0
• Wikidata: Q27107209
• NCI Thesaurus Code: C888,C175725
• RXCUI: 40144,1372638
• ChEMBL ID: CHEMBL2103741
• Mol file: 25416-65-3.mol

Synonyms:3,5,3',5'-Tetraiodothyronine;Berlthyrox;Dexnon;Eferox;Eltroxin;Eltroxine;Euthyrox;Eutirox;L Thyrox;L Thyroxin beta;L Thyroxin Henning;L Thyroxine;L Thyroxine Roche;L-3,5,3',5'-Tetraiodothyronine;L-Thyrox;L-Thyroxin beta;L-Thyroxin Henning;L-Thyroxine;L-Thyroxine Roche;Lévothyrox;Levo T;Levo-T;Levothroid;Levothyroid;Levothyroxin Deladande;Levothyroxin Delalande;Levothyroxine;Levothyroxine Sodium;Levoxine;Levoxyl;Novothyral;Novothyrox;O-(4-Hydroxy-3,5-diiodophenyl) 3,5-diiodo-L-tyrosine;O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine;Oroxine;Sodium Levothyroxine;Synthroid;Synthrox;T4 Thyroid Hormone;Thevier;Thyrax;Thyroid Hormone, T4;Thyroxin;Thyroxine;Tiroidine;Tiroxina Leo;Unithroid

Chemical Property of Levothyroxine sodium monohydrate

Chemical Property:

• Appearance/Colour: Gray to yellow powder
• Vapor Pressure: 4.02E-14mmHg at 25°C
• Melting Point: 207 °C
• Refractive Index: 1.795
• Boiling Point: 576.3oC at 760 mmHg
• Flash Point: 302.3oC
• PSA: 95.61000
• Density: 2.635g/cm³
• LogP: 3.92290
• Storage Temp.: Store at 0-5°C
• Solubility.: Very slightly soluble in water, slightly soluble in ethanol (96 per cent). It dissolves in dilute solutions of alkali hydroxides.
• Water Solubility.: 0.15 g/L (25 ºC)
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 5
• Exact Mass: 816.6792
• Heavy Atom Count: 26
• Complexity: 426

Purity/Quality:

98%,99%, ^*data from raw suppliers

L-ThyroxineSodiumHydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
• Hazard Codes: Xn:Harmful
• Statements: R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)CC(C(=O)[O-])N.O.[Na+]
• Isomeric SMILES: C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)C[C@@H](C(=O)[O-])N.O.[Na+]
• Recent ClinicalTrials: Study of XP-8121 For the Treatment of Adult Subjects With Hypothyroidism
• Recent EU Clinical Trials: A national randomized placebo-controlled double-blind multicenter trial of
• Uses: L-Thyroxine sodium hydrate is a useful research chemical. Its free form Thyroxine (T425600) is one of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia. Thyroid hormone replacement.