3'-Thymidylic acid, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, mono(5-chloro-8-quinolinyl) ester

Base Information

• Chemical Name: 3'-Thymidylic acid, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, mono(5-chloro-8-quinolinyl) ester
• CAS No.: 77735-84-3
• Molecular Formula: C₄₀H₃₇ClN₃O₁₀P
• Molecular Weight: 786.175
• Mol file: 77735-84-3.mol

Synonyms:

Chemical Property of 3'-Thymidylic acid, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, mono(5-chloro-8-quinolinyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3'-Thymidylic acid, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, mono(5-chloro-8-quinolinyl) ester

There total 2 articles about 3'-Thymidylic acid, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, mono(5-chloro-8-quinolinyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) + 3-chloro-1,2-benzisothiazole 1,1-dioxide (567-19-1) → 1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(1,1-dioxo-1H-1λ6-benzo[d]isothiazol-3-yloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione (91859-11-9) + 5'-O-dimethoxytritylthymidine 3'-(5-chloro-8-quinolyl) phosphate (77735-84-3)

Guidance literature:

With 5-chloro-8-quinolyl phosphate; In pyridine;

Reference yield: 7.0%

O-8-(5-chloroquinolyl) phosphate (71933-71-6) + 5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) → 1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(1,1-dioxo-1H-1λ6-benzo[d]isothiazol-3-yloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione (91859-11-9) + 5'-O-dimethoxytritylthymidine 3'-(5-chloro-8-quinolyl) phosphate (77735-84-3)

Guidance literature:

With BIDCl; In pyridine;

upstream raw materials:

O-8-(5-chloroquinolyl) phosphate

5'-O-(4-4'-dimethoxytrityl)thymidine

3-chloro-1,2-benzisothiazole 1,1-dioxide

Refernces