1,4-Bis(phenylsulfonyl)piperazine

Base Information

• Chemical Name: 1,4-Bis(phenylsulfonyl)piperazine
• CAS No.: 7250-99-9
• Molecular Formula: C16H18N2O4S2
• Molecular Weight: 366.462
• NSC Number: 30402,19585
• DSSTox Substance ID: DTXSID40280985
• Wikidata: Q82014705
• ChEMBL ID: CHEMBL1900283
• Mol file: 7250-99-9.mol

Synonyms:1,4-bis(phenylsulfonyl)piperazine;7250-99-9;1,4-bis(benzenesulfonyl)piperazine;NSC19585;Cambridge id 5236206;Oprea1_387006;Oprea1_497706;IFLab1_000288;SCHEMBL7122592;CHEMBL1900283;DTXSID40280985;HMS1412N02;NSC30402;CCG-15709;NSC-19585;NSC-30402;STK196082;AKOS000551781;IDI1_008507;NCGC00181874-01;EU-0068829;SR-01000406259;SR-01000406259-1;Z45410017;F0046-0029

Chemical Property of 1,4-Bis(phenylsulfonyl)piperazine

Chemical Property:

• Boiling Point: 552.6°Cat760mmHg
• Flash Point: 288°C
• Density: 1.392g/cm³
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 366.07079941
• Heavy Atom Count: 24
• Complexity: 545

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1S(=O)(=O)C2=CC=CC=C2)S(=O)(=O)C3=CC=CC=C3

Technology Process of 1,4-Bis(phenylsulfonyl)piperazine

There total 8 articles about 1,4-Bis(phenylsulfonyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.3%

benzenesulfonamide (98-10-2) + 1,2-bis-tosyloxyethane (6315-52-2) → 1,4-bis(phenylsulfonyl)piperazine (7250-99-9)

Guidance literature:

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In benzene; Heating;

Reference yield: 0.44%

piperazine (110-85-0) + benzenesulfonyl chloride (98-09-9) → 1,4-bis(phenylsulfonyl)piperazine (7250-99-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 48h; Cooling with ice;

DOI:10.2174/1573406416666200917105401

Reference yield:

Piperazin-hexahydrat + benzenesulfonyl chloride (98-09-9) → 1,4-bis(phenylsulfonyl)piperazine (7250-99-9)

Guidance literature:

With ethanol; sodium carbonate;

DOI:10.1021/ja01847a076

upstream raw materials:

benzenesulfonamide

1,2-dichloro-ethane

N,N'-bis(phenylsulfonyl)ethylenediamine

ethylene dibromide

Downstream raw materials:

1,4-dinitropiperazine

piperazine

Refernces

• 1、 Singh, Paramjit,Jain, Anupa. "Organic Synthesis Using PTC: Part 8 - Synthesis of Macrocylic Systems Containing Nitrogen and/or Oxygen as Heteroatom(s)". . p. 790 - 792. Retrieved 2007/10/02.