Acetamide, N-cyclohexyl-N-methyl-

Base Information

• Chemical Name: Acetamide, N-cyclohexyl-N-methyl-
• CAS No.: 41273-78-3
• Molecular Formula: C9H17NO
• Molecular Weight: 155.24
• Hs Code.: 2924299090
• NSC Number: 54292
• DSSTox Substance ID: DTXSID80288127
• Wikidata: Q82024419
• Mol file: 41273-78-3.mol

Synonyms:Acetamide, N-cyclohexyl-N-methyl-;41273-78-3;NSC54292;N-CYCLOHEXYL-N-METHYL-ACETAMIDE;SCHEMBL434802;N-Acetyl-N-methylcyclohexanamine;DTXSID80288127;NVEYVSRXOFPIRE-UHFFFAOYSA-N;NSC-54292;Cyclohexanamine, N-acetyl, N-methyl-;AKOS008952832

Chemical Property of Acetamide, N-cyclohexyl-N-methyl-

Chemical Property:

• Vapor Pressure: 0.0225mmHg at 25°C
• Boiling Point: 249.7°Cat760mmHg
• Flash Point: 104.6°C
• PSA: 20.31000
• Density: 0.95g/cm³
• LogP: 1.79740
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 155.131014166
• Heavy Atom Count: 11
• Complexity: 139

Purity/Quality:

99% ^*data from raw suppliers

N-CYCLOHEXYL-N-METHYL-ACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)N(C)C1CCCCC1

Technology Process of Acetamide, N-cyclohexyl-N-methyl-

There total 15 articles about Acetamide, N-cyclohexyl-N-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-methylcyclohexylamine (100-60-7) + 1-ethoxyacetylene (927-80-0) → N-cyclohexyl-N-methylacetamide (41273-78-3)

Guidance literature:

In toluene; at 180 ℃; for 0.166667h; Flow reactor;

DOI:10.1002/ejoc.201403603

Reference yield: 88.0%

N-methylcyclohexylamine (100-60-7) + acetyl chloride (75-36-5) → N-cyclohexyl-N-methylacetamide (41273-78-3)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.orglett.1c02830

Reference yield: 41.7%

methanol (67-56-1) + N-methylcyclohexylamine (100-60-7) + carbon dioxide (124-38-9,18923-20-1) → N-cyclohexyl-N-methylacetamide (41273-78-3)

Guidance literature:

With 1,3-dimethyl-2-imidazolidinone; di(rhodium)tetracarbonyl dichloride; hydrogen; lithium chloride; lithium iodide; at 190 ℃; for 14h;

DOI:10.1039/c8gc03476a

upstream raw materials:

N-methylcyclohexylamine

acetic anhydride

acetyl chloride

N,N-dimethyl-cyclohexanamine

Refernces

• 1、 Gediya, Shweta K.,Vyas, Vijyesh K.,Clarkson, Guy J.,Wills, Martin. "Asymmetric Transfer Hydrogenation of α-Keto Amides; Highly Enantioselective Formation of Malic Acid Diamides and α-Hydroxyamides". supporting information. p. 7803 - 7807. Retrieved 2021/10/20.
• 2、 Henry, Cyril,Bolien, David,Ibanescu, Bogdan,Bloodworth, Sally,Harrowven, David C.,Zhang, Xunli,Craven, Andy,Sneddon, Helen F.,Whitby, Richard J.. "Generation and trapping of ketenes in flow". . p. 1491 - 1499. Retrieved 2015/03/04.