Technology Process of 5-Azaspiro[2.5]octane-5,6,7-tricarboxylic acid, 7-(1,1-dimethylethyl)
5,6-bis(phenylmethyl) ester, (6S,7S)-
There total 20 articles about 5-Azaspiro[2.5]octane-5,6,7-tricarboxylic acid, 7-(1,1-dimethylethyl)
5,6-bis(phenylmethyl) ester, (6S,7S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
palladium diacetate;
In
diethyl ether;
at -20 - 20 ℃;
DOI:10.1021/jm061344o
- Guidance literature:
-
N-methyl-N-nitrosotoluene-p-sulfonamide;
With
potassium hydroxide;
In
diethyl ether; water;
at 60 ℃;
1,2-dibenzyl 3-tert-butyl (2S,3S)-5-methylenepiperidine-1,2,3-tricarboxylate;
With
palladium diacetate;
In
diethyl ether; water;
at -20 - 20 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 46 percent / DBU / toluene / 20 °C
2: 70 percent / K2CO3; NaI / acetonitrile / 16 h / 81 °C
3: 96 percent / NaI / acetone / 16 h / 20 °C
4: 72 percent / LiHMDS / tetrahydrofuran / 4 h / -78 - -30 °C
5: 93 percent / 28 h / 65 °C
6: 98 percent / palladium(II) acetate / diethyl ether / -20 - 20 °C
With
potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium iodide; lithium hexamethyldisilazane;
palladium diacetate;
In
tetrahydrofuran; diethyl ether; acetone; toluene; acetonitrile;
DOI:10.1021/jm061344o
