Methanesulfonic acid, trifluoro-, 2,3,6-trimethylphenyl ester

Base Information

• Chemical Name: Methanesulfonic acid, trifluoro-, 2,3,6-trimethylphenyl ester
• CAS No.: 79644-41-0
• Molecular Formula: C10H11F3O3S
• Molecular Weight: 268.257
• Mol file: 79644-41-0.mol

Synonyms:

Chemical Property of Methanesulfonic acid, trifluoro-, 2,3,6-trimethylphenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid, trifluoro-, 2,3,6-trimethylphenyl ester

There total 2 articles about Methanesulfonic acid, trifluoro-, 2,3,6-trimethylphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

trifluoromethylsulfonic anhydride (358-23-6) + 2,3,6-trimethylphenol (2416-94-6) → 2,3,6-trimethylphenyl trifluoromethanesulfonate (79644-41-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h;

Reference yield:

2,2,2-trifluoroethanol (75-89-8) + (1E,3Z)-1,4-dimethylhepta-1,3-diene-5-ynyl trifluoromethanesulphonate (93362-63-1) → (Z)-4-Methyl-oct-4-ene-2,6-diyne (79644-37-4) + 2,4-Dimethyl-1-(2,2,2-trifluoro-ethoxymethyl)-benzene (71870-61-6) + 1,2,4-Trimethyl-3-(2,2,2-trifluoro-ethoxy)-benzene (71870-59-2) + 2,3,6-trimethylphenyl trifluoromethanesulfonate (79644-41-0)

Guidance literature:

With 1,3,5-triisopropyl benzene; sodium carbonate; at 120 ℃; for 120h; Mechanism; Product distribution; D-labeld study;

Reference yield: 86.0%

methyl vinyl ketone (78-94-4,25038-87-3) + 2,3,6-trimethylphenyl trifluoromethanesulfonate (79644-41-0) → (3E)-4-(2,3,6-trimethylphenyl)but-3-en-2-one (57461-21-9,81018-77-1)

Guidance literature:

With 1,3-bis-(diphenylphosphino)propane; sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 150 ℃; for 6.5h;

DOI:10.1016/S0040-4039(98)00657-1

upstream raw materials:

2,2,2-trifluoroethanol

(1E,3Z)-1,4-dimethylhepta-1,3-diene-5-ynyl trifluoromethanesulphonate

trifluoromethylsulfonic anhydride

2,3,6-trimethylphenol

Downstream raw materials:

4-(2,3,6-trimethyl-phenyl)-butan-2-one

(3E)-4-(2,3,6-trimethylphenyl)but-3-en-2-one

Refernces

• 1、 Liu, Wenbo,Li, Jianbin,Querard, Pierre,Li, Chao-Jun. "Transition-Metal-Free C-C, C-O, and C-N Cross-Couplings Enabled by Light". supporting information. p. 6755 - 6764. Retrieved 2019/05/06.
• 2、 Hanack, Michael,Holweger, Walter. "Experimental Evidence for a Phenyl Cation Intermediate in the Solvolysis Reactions of Dienynyl Trifluoromethanesulphonates". . p. 713 - 714. Retrieved 2007/10/02.