3-Chloro-6-hydrazinopyridazine

Base Information

• Chemical Name: 3-Chloro-6-hydrazinopyridazine
• CAS No.: 17284-97-8
• Molecular Formula: C4H5ClN4
• Molecular Weight: 144.564
• Hs Code.: 2942000000
• NSC Number: 367616
• DSSTox Substance ID: DTXSID30169412
• Nikkaji Number: J364.739K
• Wikidata: Q72451693
• ChEMBL ID: CHEMBL1307732
• Mol file: 17284-97-8.mol

Synonyms:3-chloro-6-hydrazino-pyridazine;6-chloro-3-hydrazino-pyridazine;6-chloro-3-hydrazinopyridazine;ABC 907;ABC-907

Chemical Property of 3-Chloro-6-hydrazinopyridazine

Chemical Property:

• Appearance/Colour: White to pale brown crystalline powder
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 137-141 °C(lit.)
• Refractive Index: 1.684
• Boiling Point: 402.185 °C at 760 mmHg
• PKA: 5.34±0.20(Predicted)
• Flash Point: 197.034 °C
• PSA: 63.83000
• Density: 1.53 g/cm³
• LogP: 1.18890
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 144.0202739
• Heavy Atom Count: 9
• Complexity: 88.6

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Chloro-6-hydrazinopyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xn,Xi
• Statements: 22-41-43
• Safety Statements: 37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NN=C1NN)Cl
• Uses: 3-Chloro-6-Hydrazinopyridazine (cas# 17284-97-8) is a useful research chemical.

Technology Process of 3-Chloro-6-hydrazinopyridazine

There total 5 articles about 3-Chloro-6-hydrazinopyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3,6-dichlorpyridazine (141-30-0) → 3-Chloro-6-hydrazinopyridazine (17284-97-8)

Guidance literature:

With hydrazine hydrate; at 80 ℃; for 5h; Sealed tube;

Reference yield:

3,6-dichlorpyridazine (141-30-0) + aqueous hydrazine → 3-Chloro-6-hydrazinopyridazine (17284-97-8)

Guidance literature:

With ammonia; In water;

Reference yield:

6-chloro-3(2H)-pyridazinethione (3916-78-7) → 3-Chloro-6-hydrazinopyridazine (17284-97-8)

Guidance literature:

With hydrazine hydrate;

upstream raw materials:

3,6-dichlorpyridazine

6-chloro-3(2H)-pyridazinethione

Maleic hydrazide

Downstream raw materials:

1-(6-chloro-3-pyridazinyl)-5-(4-dimethylaminophenyl)pyrazole-3-carboxylic acid methyl ester

ethyl 6-chloro-<1,2,4>triazolo<4,3-b>pyridazine-3-carboxylate

5-[(1-benzyl-1H-indazol-3-yl)oxy]-2-furaldehyde (6-chloro-3-pyridazinyl)hydrazone

1-{6-[(6-chloropyridazin-3-yl)-hydrazono-(4-nitrophenyl)-methyl]-(benzo-1,3-dioxol-5-yl)}-propan-2-ol

Refernces

• 1、 Peng, Shanxi,Lv, Junfei,Liu, Gang,Fan, Congbin,Pu, Shouzhi. "A photochromic diarylethene-functionalized fluorescent probe for Cd2+ and Zn2+ detections". . . Retrieved 2020.
• 2、 Perlovich, German L.,Kazachenko, Vladimir P.,Strakhova, Nadezda N.,Schaper, Klaus-J.,Raevsky, Oleg A.. "Solubility and transfer processes of some hydrazones in biologically relevant solvents". . p. 2659 - 2667. Retrieved 2013.
• 3、 Rafi, Ummer Muhammed,Mahendiran, Dharmasivam,Haleel, Azees Khan,Nankar, Rakesh Pandeet,Doble, Mukesh,Rahiman, Aziz Kalilur. "New pyridazine-based binuclear nickel(II), copper(II) and zinc(II) complexes as prospective anticancer agents". . p. 2451 - 2465. Retrieved 2016.
• 4、 Park, Chi Hoon,Kim, Dukwoon,Jung, Hyeonseok,Jeon, Jeong Hee,Achary, Raghavendra,Lee, Joo-Youn,Kim, Pilho,Jung, Heejung,Hwang, Jong Yeon,Ryu, Do Hyun,Du Ha, Jae,Cho, Sung Yun. "Design and Synthesis of Novel 3-(2-Aminopyridin-3-yl)-1,2,4-Triazolo[4,3-b]Pyridazine Derivatives as a Reversible Bruton's Tyrosine Kinase Inhibitors". . p. 853 - 857. Retrieved 2018.
• 5、 -. "INHIBITORS OF LIN28 AND METHODS OF USE THEREOF". Page/Page column 52-53; 86. . Retrieved 2021/06/26.
• 6、 Al-Ostoot, Fares Hezam,Khanum, Shaukath Ara,M. A., Sridhar,Mohammed, Yasser Hussien Issa,Sallam, Hamdi Hamid. "Synthesis, crystal structure characterization, DFT calculations, Hirshfeld surface analysis and 3D energy frameworks of triazole pyridazine derivatives: Theoretical and experimental studies". . . Retrieved 2021/09/04.